摘要
目的研究血清微RNA(miRNA)-892b和生长相关癌基因产物β(GROβ)在胃癌中的表达水平及对患者预后的意义。方法回顾性选取2021年1月至2023年1月江苏省肿瘤医院收治的胃癌患者120例,设为胃癌组;选取同一时期入院的120名胃镜检查正常者,设为健康组。比较两组研究对象的miRNA-892b和GROβ水平,分析胃癌患者病理特征与miRNA-892b、GROβ水平的相关性,选取多因素Cox回归分析对胃癌预后的影响因素进行分析。结果胃癌组患者的miRNA-892b水平为4.01±0.21,明显低于对照组(7.99±0.45),GROβ水平为(153.91±25.18)pg/mL,明显高于对照组[(37.49±12.23)pg/mL],差异均有统计学意义(P<0.05)。不同性别、年龄的胃癌患者miRNA-892b、GROβ水平比较,差异均无统计学意义(P>0.05);不同TNM分期、淋巴结转移、肿瘤最大径及分化程度的胃癌患者miRNA-892b、GROβ水平比较,差异均有统计学意义(P<0.05)。120例胃癌患者随访12个月,88例(73.33%)存活。miRNA-892b低表达、GROβ高表达、TNM分期Ⅲ~Ⅳ期、有淋巴结转移、肿瘤最大径≥5 cm、低分化程度患者12个月总生存率均低于miRNA-892b高表达、GROβ低表达、TNM分期Ⅰ~Ⅱ期、无淋巴结转移、肿瘤最大径<5 cm、高分化程度患者,差异均有统计学意义(P<0.05)。多因素Cox回归分析结果显示,miRNA-892b低表达(HR=3.039,95%CI:1.591~5.804)、GROβ高表达(HR=2.276,95%CI:1.502~3.450)、TNM分期Ⅲ~Ⅳ期(HR=1.659,95%CI:1.014~2.714)、淋巴结转移(HR=1.790,95%CI:1.075~2.981)、低分化程度(HR=1.838,95%CI:1.047~3.226)均为胃癌预后的影响因素(P<0.05)。结论胃癌发生及发展中miRNA-892b水平下降及GROβ水平上升均有参与,miRNA-892b、GROβ表达水平变化与胃癌的病理特征及预后密切相关,可用于辅助评估预后。
Objective To investigate the expression levels of serum microRNA(miRNA)-892b and growth-related oncogene productβ(GROβ)in gastric cancer and their prognostic significance for patients.Methods A total of 120 patients with gastric cancer admitted to Jiangsu Cancer Hospital from January 2021 to January 2023 were retrospectively selected as gastric cancer group.A total of 120 patients with normal gastroscopy who were admitted to the hospital during the same period were selected as the healthy group.The levels of miRNA-892b and GROβbetween the two groups were compared,the correlation of pathological characteristics with miRNA-892b and GROβlevels of gastric cancer patients were analyzed,and the prognostic factors of gastric cancer was analyzed using multivariate Cox regression analysis.Results The level of miRNA-892b in the gastric cancer group was 4.01±0.21,which was significantly lower than that in the control group(7.99±0.45),and the level of GROβwas(153.91±25.18)pg/mL,which was significantly higher than that in the control group[(37.49±12.23)pg/mL],the differences were statistically significant(P<0.05).There were no statistically significant difference in the levels of miRNA-892b and GROβin gastric cancer patients with different genders and ages(P>0.05).There were statistically significant differences in the levels of miRNA-892b and GROβin gastric cancer patients with different TNM stages,lymph node metastasis,tumor maximum diameter and differentiation degree(P<0.05).A total of 120 patients with gastric cancer were followed up for 12 months,and 88(73.33%)survived.The 12-month overall survival rate of patients with low expression of miRNA-892b,high expression of GROβ,TNM stageⅢ-Ⅳ,lymph node metastasis,tumor maximum diameter≥5 cm and poor differentiation were lower than that of patients with high expression of miRNA-892b,low expression of GROβ,TNM stageⅠ-Ⅱ,no lymph node metastasis,tumor maximum diameter<5 cm and high differentiation(P<0.05).Multivariate Cox regression analysis showed that low expression of miRNA-892b(HR=3.039,95%CI:1.591-5.804),high expression of GROβ(HR=2.276,95%CI:1.502-3.450),TNM stageⅢ-Ⅳ(HR=1.659,95%CI:1.014-2.714),lymph node metastasis(HR=1.790,95%CI:1.075-2.981),and poor differentiation(HR=1.838,95%CI:1.047-3.226)were all prognostic factors of gastric cancer(P<0.05).Conclusion Both the increase of GROβlevel and the decrease of miRNA-892b are involved in the occurrence and development of gastric cancer.The changes of GROβand miRNA-892b expression levels are closely related to the pathological characteristics and prognosis,and can be used to assist in the assessment of prognosis.
作者
师妍
潘旋
濮家琳
SHI Yan;PAN Xuan;PU Jia-lin(Department of Medical Oncology,Jiangsu Cancer Hospital,Nanjing Jiangsu 210000,China)
出处
《临床和实验医学杂志》
2025年第10期1035-1038,共4页
Journal of Clinical and Experimental Medicine
基金
江苏省卫生健康委科研项目(编号:LGY2019076)。
