摘要
线粒体是细胞代谢程序的核心,为各种细胞功能提供必要的能量和分子前体,并影响信号传导途径和基因表达。T淋巴细胞是介导抗肿瘤免疫的核心,特别是CD8^(+)T细胞被认为是参与抗肿瘤免疫过程的主要免疫细胞。线粒体中的代谢物、酶和转运蛋白等代谢检查点通过信号传导通路使线粒体内发生代谢重编程或通过诱导关键基因表观遗传学的改变,从而改变CD8^(+)T细胞的分化和效应功能。本文综述肿瘤微环境中CD8^(+)T细胞内的线粒体结构,功能和代谢特征及代谢检查点对其抗肿瘤功能的调控机制。靶向这些线粒体代谢检查点可能改变CD8^(+)T细胞分化方向,增强CD8^(+)T细胞的抗肿瘤能力,为未来恶性肿瘤靶向治疗策略提供新的科学依据和研究思路。
Mitochondrion are the core of cellular metabolic programs,providing necessary energy and molecular precursors for various cellular functions,and affecting signaling pathways and gene expression.T lymphocytes are the core of mediating anti-tumor immunity,especially CD8^(+)T cells,which are considered the main immune cells involved in anti-tumor immune process.Metabolic checkpoints of metabolites,enzymes,and transporters in mitochondrion undergo metabolic reprogram-ming through signaling pathways or induce epigenetic changes in key genes,thereby altering the differentiation and effector function of CD8^(+)T cells.This article reviews mitochondrial structure,function,and metabolic characteristics of CD8^(+)T cells in the tumor microenvironment,as well as the regulatory mechanisms of metabolic checkpoints on their anti-tumor function.Targeting these mitochondrial metabolic checkpoints may alter the differentiation direction of CD8^(+)T cells,enhance their anti-tumor ability,and provide new scientific basis and research ideas for future targeted therapy strategies for malignant tumors.
作者
艾佳琦
牛怡然
周琼
AI Jiaqi;NIU Yiran;ZHOU Qiong(Department of Respiratory Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province,Wuhan 430022,China;Department of Respiratory Medicine,Wuhan Central Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Hubei Province,Wuhan 430014,China)
出处
《中国医药导报》
2025年第14期60-64,共5页
China Medical Herald
基金
国家自然科学基金青年科学基金资助项目(82400119)
湖北省武汉市知识创新专项曙光计划项目(2023020201020543)。
