摘要
目的:分析2020—2023年耐碳青霉烯类肺炎克雷伯菌(CRKP)分布及耐药性。方法:收集2020—2023年该院各临床科室送检的标本的临床资料,统计肺炎克雷伯菌(KP)和CRKP检出情况、CRKP检出标本类型、不同科室CRKP检出情况,分析CRKP对常见抗菌药物的耐药性。结果:2020—2023年各临床科室送检的标本中,共检出1728株KP,438株CRKP,检出率呈先降低后升高的趋势;CRKP主要在痰液标本中检出,占56.62%,其次为肺泡灌洗液、尿液标本,占17.12%、15.07%;重症监护病房(ICU)科室中,呼吸ICU的CRKP检出率呈先升高后降低的趋势;非ICU科室中,神经外科病区CRKP检出率呈先降低后升高的趋势;呼吸ICU、神经外科病区、综合ICU和呼吸内科病区CRKP检出率均较高;CRKP对β-内酰胺类、喹诺酮类、氨基糖苷类抗生素的耐药性均较高,对米诺环素的耐药性较低,对多黏菌素无耐药性;2023年增加替加环素和头孢他啶/阿维巴坦的耐药性分别为41.82%、6.06%。结论:CRKP主要在痰液标本中检出,主要分布于呼吸ICU、神经外科病区、综合ICU和呼吸内科病区,对β-内酰胺类、喹诺酮类、氨基糖苷类抗生素的耐药性均较高,对米诺环素的耐药性较低,对多黏菌素无耐药性。
Objective:To analyze distribution and drug resistance of Carbapenem-resistant Klebsiella pneumoniae(CRKP)from 2020 to 2023.Methods:The clinical data of the specimens of cultured in various clinical departments of the hospital from 2020 to 2023 were collected.The detection of Klebsiella pneumoniae(KP)and CRKP,the types of CRKP specimens and the detection of CRKP in different departments were statistically analyzed.Further,the drug resistance of CRKP to common antibiotics was analyzed.Results:1728 strains of KP and 438 strains of CRKP were detected in the specimens submitted by the clinical departments from 2020 to 2023,and the detection rate showed a trend of decreasing first and then increasing.CRKP was mainly detected in the sputum samples,accounting for 56.62%,followed by alveolar lavage fluid and urine samples,accounting for 17.12%and 15.07%,respectively.In intensive care unit(ICU),the detection rate of CRKP in respiratory ICU increased first and then decreased.In non-ICU departments,the detection rate of CRKP in neurosurgery ward decreased first and then increased.The detection rates of CRKP in respiratory ICU,neurosurgery ward,comprehensive ICU and respiratory medicine ward were higher.The resistance rates of CRKP toβ-lactams,Quinolones,and Aminoglycosides were high,the resistance rate to Minocycline was low,and there was no resistance to Polymyxin.In 2023,the resistance rates of CRKP to Tigecycline and Ceftazidime/Avibactam increased by 41.82%and 6.06%,respectively.Conclusions:CRKP is mainly detected in the sputum samples and mainly distributed in the respiratory ICU,neurosurgery ward,comprehensive ICU and respiratory medicine ward.Further,the resistance rates of CRKP toβ-lactams,Quinolones and Aminoglycosides are high,the resistance rate to Minocycline was low,and there is no resistance to Polymyxin.
作者
李媛媛
郭宾
程松
徐慧
LI Yuanyuan;GUO Bin;CHENG Song;XU Hui(The First Affiliated Hospital of Nanyang Medical College,Infection Prevention and Control Department,Nanyang 473000 Henan,China;The First Affiliated Hospital of Nanyang Medical College,Department of Clinical Laboratory,Nanyang 473000 Henan,China;The First Affiliated Hospital of Nanyang Medical College,Nutrition Department,Nanyang 473000 Henan,China)
出处
《中国民康医学》
2025年第11期26-29,共4页
Medical Journal of Chinese People’s Health
关键词
耐碳青霉烯类肺炎克雷伯菌
检出率
耐药性
Carbapenem-resistant Klebsiella pneumoniae
Detection rate
Drug resistance
