摘要
目的探讨吲达帕胺联合卡托普利对高血压患者炎症因子的影响。方法选择80例高血压患者为研究对象,按照随机数字表法分为对照组及观察组,各40例。对照组使用硝苯地平缓释片治疗,观察组在硝苯地平缓释片的基础上口服吲达帕胺片联合卡托普利治疗。比较两组治疗后的脂联素、超敏C反应蛋白及肿瘤坏死因子-α水平,治疗前后的左室射血分数,治疗1个疗程后的血压达标情况。结果治疗后,观察组脂联素(6.1±1.3)μg/ml高于对照组的(3.1±0.7)μg/ml,超敏C反应蛋白(6.4±0.8)mg/L、肿瘤坏死因子-α(4.5±0.6)pg/ml低于对照组的(12.3±1.5)mg/L、(10.9±2.0)pg/ml(P<0.05)。治疗前,两组左室射血分数比较,差异无统计学意义(P>0.05);治疗后,两组左室射血分数高于治疗前,且观察组左室射血分数(66.2±8.6)%显著高于对照组的(55.7±5.1)%(P<0.05)。治疗1个疗程后,观察组的随机血压达标率97.5%、诊室血压达标率95.0%、动态血压达标率92.5%高于对照组的75.0%、72.5%、70.0%(P<0.05)。结论吲达帕胺联合卡托普利治疗高血压可显著提高血清脂联素水平,降低肿瘤坏死因子-α和超敏C-反应蛋白水平,改善心脏功能,提高血压控制效果。
Objective To explore the effect of indapamide combined with captopril on inflammatory factors in patients with hypertension.Methods A total of 80 patients with hypertension were selected as the study subjects and divided into a control group and an observation group according to random numerical table,with 40 cases in each group.The control group was treated with nifedipine sustained-release tablets,and the observation group was treated with indapamide tablets combined with captopril on the basis of nifedipine sustained-release tablets.Comparison of levels of adiponectin,hypersensitive C-reactive protein and tumor necrosis factor-αafter treatment,left ventricular ejection fraction before and after treatment,and blood pressure control status after 1 course of treatment between the two groups.Results After treatment,the observation group had a higher adiponectin of(6.1±1.3)μg/ml than(3.1±0.7)μg/ml in the control group;the hypersensitive C-reactive protein and tumor necrosis factor-αwere(6.4±0.8)mg/L and(4.5±0.6)pg/ml in the observation group,which were lower than(12.3±1.5)mg/L and(10.9±2.0)pg/ml in the control group(P<0.05).Before treatment,there was no significant difference in left ventricular ejection fraction between the two groups(P>0.05).After treatment,the left ventricular ejection fraction in both groups was higher than that before treatment,and the left ventricular ejection fraction of(66.2±8.6)%in the observation group was significantly higher than(55.7±5.1)%in the control group(P<0.05).After 1 course of treatment,the random blood pressure control rate of the observation group was 97.5%,the clinic blood pressure control rate was 95.0%,and the ambulatory blood pressure control rate was 92.5%,which were higher than 75.0%,72.5%,and 70.0%of the control group(P<0.05).Conclusion Indapamide combined with captopril for the treatment of hypertension can significantly improve the level of serum adiponectin,reduce the level of tumor necrosis factor-αand hypersensitive C-reactive protein,improve heart function and improve blood pressure control effect.
作者
李静
LI Jing(Internal Medicine Department,Tianjin Peking University Medical Offshore Oil Hospital,Tianjin 300450,China)
出处
《中国实用医药》
2025年第11期12-15,共4页
China Practical Medicine
