摘要
目的:比较眼三针透刺联合玻璃酸钠滴眼液与单纯玻璃酸钠滴眼液治疗干眼的临床疗效。方法:将156例(312只眼)干眼患者随机分为观察组和对照组,每组78例(156眼)。对照组予玻璃酸钠滴眼液滴眼,每次每眼1滴,每天4次,共治疗4周;观察组在对照组基础上,予眼三针透刺,穴取双侧攒竹、丝竹空、四白及睛明,每天1次,每周4次,共治疗4周。观察两组患者治疗前后眼部主观症状评分、眼神经痛(NPSI-Eye)评分、眼表疾病指数(OSDI)评分、角膜荧光素染色(FL)评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、中央泪河高度(TMH)及泪液白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)含量,并比较两组临床疗效。结果:与治疗前比较,两组患者治疗后眼部主观症状评分、NPSI-Eye评分、OSDI评分、FL评分及泪液IL-6、TNF-α含量降低(P<0.01),BUT、SⅠT、TMH增加(P<0.01);治疗后,观察组患者眼部主观症状评分、NPSI-Eye评分、OSDI评分、FL评分及泪液IL-6、TNF-α含量低于对照组(P<0.01,P<0.05),BUT、SⅠT、TMH优于对照组(P<0.01)。观察组显效率和总有效率分别为83.3%(65/78)、100.0%(78/78),高于对照组的52.6%(41/78,P<0.01)、92.3%(72/78,P<0.05)。结论:眼三针透刺联合玻璃酸钠滴眼液治疗可缓解干眼患者症状,减轻炎性反应,疗效优于单纯玻璃酸钠滴眼液。
Objective To compare the clinical efficacy between penetrating needling of three eye acupoints combined with sodium hyaluronate eye drops and sodium hyaluronate eye drops alone for the treatment of dry eye.Methods A total of 156 patients(312 eyes)with dry eye were randomly assigned to an observation group and a control group,with 78 patients(156 eyes)in each group.The control group was treated with sodium hyaluronate eye drops,one drop per eye,four times daily,for 4 weeks.In addition to the sodium hyaluronate treatment,the observation group received penetrating needling of three eye acupoints.Acupoints included bilateral Cuanzhu(BL2),Sizhukong(TE23),Sibai(ST2),and Jingming(BL1).Needling was performed once daily,four times a week,for 4 weeks.The subjective ocular symptom scores,neuropathic pain symptom inventory-eye(NPSI-Eye)scores,ocular surface disease index(OSDI)scores,corneal fluorescein staining(FL)scores,tear break-up time(BUT),SchirmerⅠtest(SⅠT),central tear meniscus height(TMH),and tear levels of interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)were evaluated before and after treatment in the two groups.Clinical efficacy was also compared between the two groups.Results After treatment,both groups showed significant improvements in subjective ocular symptom scores,NPSI-Eye scores,OSDI scores,FL scores,and reductions in tear IL-6 and TNF-αlevels(P<0.01).Additionally,BUT,SⅠT,and TMH were increased significantly in both groups(P<0.01).After treatment,the subjective ocular symptom scores,NPSI-Eye score,OSDI score,FL score,and tear levels of IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.01,P<0.05),while BUT,SⅠT,and TMH were significantly improved compared to the control group(P<0.01).The markedly effective rate and total effective rate in the observation group were 83.3%(65/78)and 100.0%(78/78),respectively,which were higher than 52.6%(41/78,P<0.01)and 92.3%(72/78,P<0.05)in the control group.Conclusion The penetrating needling of three eye acupoints combined with sodium hyaluronate eye drops can effectively alleviate symptoms of dry eye,reduce inflammatory response,and has superior efficacy to sodium hyaluronate eye drops alone.
作者
陈垂海
王宇杰
CHEN Chuihai;WANG Yujie(Ophthalmology Department,Bao'an District TCM Hospital,Shenzhen 518133,Guangdong Province,China;Pediatric Neurological Rehabilitation Department,Shenzhen Maternity and Child Healthcare Hospital)
出处
《中国针灸》
北大核心
2025年第5期633-637,共5页
Chinese Acupuncture & Moxibustion
关键词
干眼
针刺
透刺
眼三针
玻璃酸钠滴眼液
随机对照试验
Sdry eye
acupuncture
penetrating needling
three eye acupoints
sodium hyaluronate eye drops
randomized controlledtrial(RCT)
