摘要
脑卒中是一种由血管意外引起的常见神经系统疾病。中枢性卒中后疼痛(CPSP)作为脑卒中后难治症状之一,其发病时间不一,临床症状各异,极大影响患者的生活质量,甚至导致患者自杀。其发病机制至今尚不明确,临床通常的治疗手段包括药物治疗和作为辅助的神经调控疗法等,但效果欠佳。笔者综述近年来关于CPSP的研究进展,从组织、细胞、分子等层面探讨其发病机制以及临床治疗方法,以期为CPSP的基础研究和临床治疗提供新的角度。
Stroke is a common neurological disorder caused by cerebrovascu lar events.Central post-stroke pain(CPSP)is a refractory complication of stroke characterized by variable onset times and diverse clinical manifestations.Its clinical management often yields poor therapeutic outcomes,significantly impairing patients'quality of life and even leading to suicidal tendencies in some cases.The pathogenesis of CPSP remains elusive.Current clinical treatments,including pharmacotherapy and adjunctive neuromodulatory therapies,have shown limited efficacy.This paper reviews recent advances in CPSP research from the perspectives of tissue,cellular,and molecular levels.It also discusses CPSP clinical treatment methods,aiming to provide new perspectives for both basic research and clinical management of CPSP.
作者
裴笑楠
赵森
臧卫东
Pei Xiaonan;Zhao Sen;Zang Weidong(Department of Human Anatomy,School of Basic Medical Science,Zhengzhou University,Zhengzhou 450001,China)
出处
《解剖学杂志》
2025年第2期161-164,共4页
Chinese Journal of Anatomy
关键词
卒中
疼痛
信号通路
神经炎症
胶质细胞
stroke
pain
signal pathway
neuroinflammation
glial cells
