摘要
目的分析消化道肿瘤患者采用卡培他滨联合奥沙利铂治疗的效果及对生活质量的影响。方法选择80例消化道肿瘤患者,根据随机数字表法分为对照组和观察组,每组40例。对照组接受替吉奥+奥沙利铂治疗,观察组接受卡培他滨+奥沙利铂治疗。对比两组治疗效果、血清肿瘤标志物、生活质量、不良反应发生率。结果观察组治疗总有效率(90.00%)高于对照组(72.50%),差异有统计学意义(P<0.05)。治疗后,两组癌胚抗原、糖类抗原125、糖类抗原19-9均较治疗前降低,且观察组癌胚抗原(2.19±0.38)μg/L、糖类抗原125(12.17±2.67)U/ml、糖类抗原19-9(14.51±2.67)U/ml均低于对照组的(4.89±0.89)μg/L、(30.49±4.51)U/ml、(28.90±3.76)U/ml,差异有统计学意义(P<0.05)。治疗后,两组心理功能、躯体功能、社会功能、物质生活状态评分均高于同组治疗前,且观察组心理功能评分(74.54±4.61)分、躯体功能评分(75.67±4.51)分、社会功能评分(77.67±3.78)分、物质生活状态评分(74.51±4.51)分均高于对照组的(66.78±6.72)、(70.34±3.18)、(70.23±4.51)、(68.98±4.55)分,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论消化道肿瘤患者给予卡培他滨+奥沙利铂治疗的效果好,安全性高,可以更好地提高患者生活质量,值得借鉴。
Objective To analyze the effect of capecitabine combined with oxaliplatin in the treatment of digestive tract tumors and its influence on quality of life.Methods A total of 80 patients with digestive tract tumors were selected and divided into control group and observation group according to random numerical table,with 40 cases in each group.The control group was treated with tegafur+oxaliplatin,and the observation group was treated with capecitabine+oxaliplatin.The therapeutic effect,serum tumor markers,quality of life score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(90.00%)was higher than that of the control group(72.50%),and the difference was statistically significant(P<0.05).After treatment,the carcinoembryonic antigen,carbohydrate antigen 125 and carbohydrate antigen 19-9 were decreased in both groups compared with before treatment;in the observation group,the carcinoembryonic antigen was(2.19±0.38)μg/L,the carbohydrate antigen 125 was(12.17±2.67)U/ml,and the carbohydrate antigen 19-9 was(14.51±2.67)U/ml,which were lower than(4.89±0.89)μg/L,(30.49±4.51)U/ml and(28.90±3.76)U/ml in the control group;the difference was statistically significant(P<0.05).After treatment,the scores of psychological function,physical function,social function and material life status in both groups were higher than those before treatment;in the observation group,the psychological function score was(74.54±4.61)points,the physical function score was(75.67±4.51)points,the social function score was(77.67±3.78)points,and the material life status score was(74.51±4.51)points,which were higher than(66.78±6.72),(70.34±3.18),(70.23±4.51),and(68.98±4.55)points in the control group;the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Capecitabine+oxaliplatin has good effect and high safety on patients with digestive tract tumors,and can better improve the quality of life of patients,which is worthy of reference.
作者
王传营
刘鹏
陈童
WANG Chuan-ying;LIU Peng;CHEN Tong(University Town Hospital,Affiliated Hospital of Shandong University of Traditional Chinese Medicine(Changqing District People's Hospital),Jinan 250300,China)
出处
《中国现代药物应用》
2025年第10期110-113,共4页
Chinese Journal of Modern Drug Application
关键词
消化道肿瘤
卡培他滨
奥沙利铂
治疗效果
安全性
生活质量
Digestive tract tumors
Capecitabine
Oxaliplatin
Therapeutic effect
Security
Quality of life
