摘要
目的分析急性脑梗死患者采取氯吡格雷联合阿司匹林治疗的效果及对炎性因子的影响。方法选择60例急性脑梗死患者,随机分为联合用药组和单纯用药组,各30例。单纯用药组采取单一阿司匹林治疗,联合用药组采取氯吡格雷联合阿司匹林治疗。对比两组患者的治疗效果、不良反应发生率、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、炎性指标[白细胞介素-10(IL-10)、白细胞介素-4(IL-4)、单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)]、凝血功能指标[血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)]。结果联合用药组患者治疗后NIHSS评分(11.05±1.26)分低于单纯用药组的(14.21±2.63)分,Barthel指数(88.52±5.26)分高于单纯用药组的(72.62±4.92)分(P<0.05)。联合用药组患者治疗后IL-10水平高于单纯用药组,IL-4、MCP-1、TNF-α、IL-1β、IL-6、hs-CRP、WBC水平均低于单纯用药组(P<0.05)。联合用药组患者治疗后PLT(264.52±38.16)×10^(9)/L、Fib(2.33±0.62)g/L低于单纯用药组的(298.52±33.42)×10^(9)/L、(3.68±0.64)g/L,PT(11.62±1.48)s、APTT(33.72±3.62)s长于单纯用药组的(10.22±1.33)、(27.52±3.56)s(P<0.05)。联合用药组治疗总有效率96.67%高于单纯用药组的76.67%(P<0.05)。联合用药组与单纯用药组患者不良反应发生率对比无较大差异(P>0.05)。结论急性脑梗死患者通过氯吡格雷联合阿司匹林治疗效果良好,患者的神经功能缺损和生活能力都得到好转,炎性指标及凝血功能指标也得到改善,患者的生活质量明显提高。
Objective To analyze the effect of clopidogrel combined with aspirin in the treatment of acute cerebral infarction and its impact on inflammatory factors.Methods 60 patients with acute cerebral infarction were randomly divided into combination therapy group and monotherapy group,with 30 cases in each group.The monotherapy group was treated with aspirin alone,and the combination therapy group was treated with clopidogrel combined with aspirin.Patients in both groups were compared in terms of therapeutic effect,incidence of adverse reactions,National Institutes of Health Stroke Scale(NIHSS)score,Barthel index,inflammatory indicators[interleukin-10(IL-10),interleukin-4(IL-4),monocyte chemotactic protein-1(MCP-1),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),white blood cell count(WBC)],coagulation function indicators[platelet count(PLT),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fib)].Results After treatment,the combination therapy group had a lower NIHSS score of(11.05±1.26)points than(14.21±2.63)points in the monotherapy group,and a higher Barthel index of(88.52±5.26)points than(72.62±4.92)points in the monotherapy group(P<0.05).After treatment,IL-10 level in the combination therapy group was higher than that in the monotherapy group,and the levels of IL-4,MCP-1,TNF-α,IL-1β,IL-6,hs-CRP and WBC were lower than those in the monotherapy group(P<0.05).After treatment,the combination therapy group had PLT of(264.52±38.16)×10^(9)/L and Fib of(2.33±0.62)g/L,which were lower than(298.52±33.42)×10^(9)/L and(3.68±0.64)g/L in the monotherapy group;the combination therapy group had PT of(11.62±1.48)s and APTT of(33.72±3.62)s,which were longer than(10.22±1.33)and(27.52±3.56)s in the monotherapy group(P<0.05).The total effective rate of the combination therapy group was 96.67%,which was higher than that of the monotherapy group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combination therapy group and the monotherapy group(P>0.05).Conclusion Clopidogrel combined with aspirin shows good effect on patients with acute cerebral infarction,which can improve the neurological deficits,living ability,inflammatory indicators,coagulation function indexes,and significantly improve the quality of life of patients.
作者
林明钦
LIN Ming-qin(Department of Pharmacy,Dongshan County Hospital,Zhangzhou 363400,China)
出处
《中国现代药物应用》
2025年第10期17-20,共4页
Chinese Journal of Modern Drug Application
关键词
氯吡格雷
阿司匹林
急性脑梗死
神经功能缺损
炎性因子
应用效果
Clopidogrel
Aspirin
Acute cerebral infarction
Neurological deficit
Inflammatory factors
Application effect
