摘要
骨骼疾病影响着全球大量人口的健康,并给医疗体系带来了巨大负担。在纳米递药系统(nano drug delivery systems,NDDS)领域,阿仑膦酸盐(alendronate,ALN)作为高亲骨性化合物,因其具有高效的骨靶向机制而成为NDDS负载药物治疗骨骼疾病的理想骨靶向配体。在骨骼疾病的治疗中,经ALN修饰的NDDS可高效地将药物递靶向递送至骨组织、有效地提高药物疗效、减少传统给药方式的不良反应等优势。本文对ALN在NDDS领域中的研究进展进行归纳总结,以期为骨靶向配体ALN修饰的NDDS的进一步发展提供帮助。
Bone diseases affect the health of a large population globally and impose a significant burden on healthcare systems.In the field of Nanodrug Delivery Systems(NDDS),alendronate(ALN),a compound with high bone affinity,has emerged as an ideal bone-targeting ligand for drug delivery in the treatment of skeletal diseases due to its efficient bone-targeting mechanism.ALN-modified NDDS can effectively deliver drugs to bone tissue,improve therapeutic efficacy,and reduce the adverse effects associated with traditional drug delivery methods.This review summarizes the research progress of ALN in the NDDS field,with the aim of providing assistance for the further development of ALN-modified NDDS as bone-targeting drug delivery systems.
作者
廖华远
郭嘉忱
蒋优
孔泳
张曦
高俊
LIAO Hua-yuan;GUO Jia-chen;JIANG You;KONG yong;ZHANG Xi;GAO Jun(Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China;不详)
出处
《广东医学》
2025年第4期634-640,共7页
Guangdong Medical Journal
基金
国家自然科学基金资助项目(82374479)。
关键词
阿仑膦酸盐
骨靶向
纳米递药系统
骨骼疾病
alendronate
bone targeting
nanodrug delivery systems
skeletal diseases
