摘要
随着对遗传性非息肉病性结直肠癌或林奇综合征研究深入,越来越多的研究发现微卫星不稳定性(microsatellite instability,MSI)在恶性肿瘤发生、发展中发挥了重要作用。MSI作为子宫内膜癌的重要发病机制之一,在疾病的治疗选择以及预后评估等方面均展现出了重要的临床价值。MSI可指导程序性死亡配体-1(PD-L1)免疫抑制剂在特定类型子宫内膜癌中的应用。Apelin作为一种脂肪因子,被认为与子宫内膜癌的发生发展有关,Apelin可通过上调B淋巴细胞瘤基因-2(Bcl-2)和下调B淋巴细胞瘤-2相关X蛋白(Bax)的表达而抑制子宫内膜癌的细胞凋亡。然而,目前关于MSI与Apelin相互作用及其对抗肿瘤免疫治疗的研究较少,且大多数研究为回顾性分析。因此,本文将就MSI及Apelin对子宫内膜癌病情进展和抗肿瘤免疫治疗的作用和机制作一综述。
With increasing research on hereditary nonpolyposis colorectal cancer and Lynch syndrome,microsatellite instability(MSI)has been recognized as playing a critical role in the development and progression of various malignancies.As one of the key pathogenic mechanisms in endometrial cancer,MSI shows significant clinical value in guiding treatment decisions and evaluating prognosis.Notably,MSI can inform the use of PD-LI immune checkpoint inhibitors in specific subtypes of endometrial cancer.Apelin,an adipokine,has also been implicated in the pathogenesis of endometrial cancer,where it inhibits apoptosis by upregulating Bcl-2 and downregulating Bax expression.However,studies exploring the interplay between MSI and Apelin in the context of antitumor immunity remain limited,with most current evidence derived from retrospective analyses.This review summarizes the current understanding of the roles and mechanisms of MSI and Apelin in endometrial cancer progression and their implications for immunotherapy.
作者
陈秋燕
戴仕芬
陈启城
邹俊涛
CHEN Qiu-yan;DAI Shi-fen;CHEN Qi-cheng;ZOU Jun-lao(Department of Gynecology,Meizhou People's Hospital,Meizhou 514031,Guangdong,China;不详)
出处
《广东医学》
2025年第5期791-796,共6页
Guangdong Medical Journal
基金
广东省自然科学基金项目(2022A1515010690)
梅州市人民医院科研培育项目(PY-C2024019)。
