摘要
[目的]优化除草剂茚嗪氟草胺的合成路线,以缩短反应时间、简化反应操作和提高产品纯度。[方法]以2,6-二甲基-1-茚酮为起始原料,经不对称氢化、光延反应、施陶丁格还原、亲核加成和环化反应合成目标化合物,并对关键步骤的反应条件进行了优化。[结果]通过5步反应得到茚嗪氟草胺,总收率41.5%(以2,6-二甲基-1-茚酮计),产品含量97.3%。[结论]此工艺原料易得,操作简便,产品含量高,为茚嗪氟草胺及其类似物的合成提供了参考。
[Aims]The aim is to optimize the synthetic route of herbicide indaziflam,in order to shorten the reaction time,simplify the reaction operation and improve the purity of the product.[Methods]With 2,6-dimethyl-2,3-dihydro-1H-inden-1-one as the starting material,the target compound was synthesized through asymmetric hydrogenation,Mitsunobu reaction,Staudinger reduction,nucleophilic addition and cyclization,and the reaction conditions of the key steps were optimized.[Results]Indaziflam was synthesized by a 5-step reaction sequence with a total yield of 41.5%(based on 2,6-dimethyl-2,3-dihydro-1H-inden-1-one)and a purity of 97.3%.[Conclusions]This method has advantages of readily available materials,simple operation and high purity,which provides a reference for the synthesis of indaziflam and its analogues.
作者
吴鑫
王金山
张科
庄德伟
孙永辉
孔繁蕾
潘建明
WU Xin;WANG Jinshan;ZHANG Ke;ZHUANG Dewei;SUN Yonghui;KONG Fanlei;PAN Jianming(Jiangsu Agrochem Laboratory Co.,Ltd.,Changzhou 213022,Jiangsu,China;School of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,Jiangsu,China)
出处
《农药》
北大核心
2025年第5期328-331,共4页
Agrochemicals
