摘要
目的 探讨血清受体相互作用蛋白3(RIP3)、可溶性髓样细胞触发受体-1(sTREM-1)水平与新生儿败血症(NS)病情严重程度的关系及其预后预测价值。方法 选择84例NS患儿(NS组)进行研究,根据新生儿危重评分将患儿分为非危重组(n=34)、危重组(n=26)与极危重组(n=24)。根据患儿1个月预后将其分为预后良好组(n=56)与预后不良组(n=28)。对比不同组别患儿血清RIP3、sTREM-1水平,用Logistic回归模型分析NS患儿预后的危险因素,并通过受试者工作特征(ROC)曲线评价RIP3、sTREM-1对预后的预测价值。结果 不同病情NS患儿血清RIP3、sTREM-1水平差异显著(P<0.05),随着病情加重,患儿血清RIP3、sTREM-1水平逐渐增高(P<0.05)。预后不良组患儿血清PCT、RIP3、sTREM-1水平显著高于预后良好组(P<0.05)。Logistic回归分析,得出血清RIP3、sTREM-1水平增高为NS患儿预后不良的危险因素(P<0.05)。ROC曲线得出,血清RIP3预测预后的AUC为0.760,sTREM-1预测预后的AUC为0.763,且二者联合的AUC更大,达到0.849。结论 血清RIP3、sTREM-1水平与NS病情严重程度密切相关,对预后有较高预测价值,可作为临床评估的参考指标。
Objective To investigate the relationship between serum receptor-interacting protein 3(RIP3),soluble triggering receptor expressed on myeloid cells-l(sTREM-1)levels and severity of disease of neonatal sepsis(NS)and its prognostic value.Methods A total of 84 children with NS(NS group)were selected and divided into non-critical group(n=34),critical group(n=26)and extremely critical group(n=24)according to the neonatal critical score.According to the prognosis of 1 month,the patients were divided into good prognosis group(n=56)and poor prognosis group(n=28).The levels of serum RIP3 and sTREM-1 in different groups were compared.Logistic regression model was used to analyze the risk factors of prognosis in children with NS,and the predictive value of RIP3 and sTREM-1 on prognosis was evaluated by receiver operating characteristic(ROC)curve.Results The levels of serum RIP3 and sTREM-1 in NS children with different conditions were significantly different(P<0.05).With the aggravation of the disease,the levels of serum RIP3 and sTREM-1 gradually increased(P<0.05).The levels of serum PCT,RIP3 and sTREM-1 in the good prognosis group were significantly higher than those in the poor prognosis group(P<0.05).Logistic regression analysis showed that increased serum RIP3 and sTREM-1 levels were risk factors for poor prognosis in children with NS(P<0.05).ROC curve showed that the AUC of serum RIP3 for predicting prognosis was 0.760,the AUC of sTREM-1 for predicting prognosis was O.763,and the AUC of the combination of the two was greater,reaching 0.849.Conclusion Serum RIP3 and sTREM-1 levels are closely related to the severity of NS,which can have a high predictive value for prognosis and can be used as reference indicators for clinical evaluation.
作者
胡雨润
高恶斌
HU Yurun;GAO Ebin(College of Life Sciences,Jiangsu University,Zhenjiang,Jiangsu 212013,China;Ningbo Women and Children Hospital,Ningbo,Zhejiang 315000,China)
出处
《中国实验诊断学》
2025年第5期527-531,共5页
Chinese Journal of Laboratory Diagnosis
基金
宁波市科技局科技计划项目(2022S127)。
