摘要
目的银杏叶提取物注射液在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺性脑病(PE)患者中的应用效果。方法选择2022年4月至2024年6月濮阳市中医医院收治的88例AECOPD合并PE患者作为研究对象,依据随机数表法分为观察组和对照组各44例。对照组患者采用常规治疗,观察组患者在对照组治疗的基础上采用银杏叶提取物注射液治疗,所有患者均治疗2周。比较两组患者治疗前后的慢性阻塞性肺疾病评分(CAT)、蒙特利尔认知评估量表(MoCA)评分、肺功能[用力肺活量(FVC)、第一秒用力呼气容积(FEV1),FEV1/FVC比值]、炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、白介素-6(IL-6)水平]和免疫功能[CD3^(+)、CD4^(+)、CD8^(+)水平,CD4^(+)/CD8^(+)],同时比较两组患者治疗期间的不良反应发生情况。结果治疗前,两组患者的CAT评分和MoCA评分比较差异均无统计学意义(P>0.05);治疗2周后,观察组患者的CAT评分为(20.03±1.74)分,明显低于对照组的(24.41±1.90)分,MoCA评分为(27.11±2.46)分,明显高于对照组的(24.30±2.19)分,差异均有统计学意义(P<0.05)。治疗前,两组患者的肺功能指标比较差异无统计学意义(P>0.05);治疗2周后,观察组患者的肺功能指标明显高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者的TNF-α、IL-8、IL-6比较差异均无统计学意义(P>0.05);治疗2周后,观察组患者的TNF-α、IL-8、IL-6分别为(13.36±2.38)pg/mL、(20.66±3.31)pg/mL、(16.87±2.11)pg/mL,明显低于对照组的(18.74±3.34)pg/mL、(29.94±5.19)pg/mL、(22.70±2.79)pg/mL,差异均有统计学意义(P<0.05)。治疗前,两组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比较差异均无统计学意义(P>0.05);治疗2周后,观察组患者的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)明显高于对照组,CD8^(+)明显低于对照组,差异均有统计学意义(P<0.05)。治疗期间,两组患者均无明显不良反应情况。结论银杏叶提取物注射液可提高AECODP合并PE患者的临床治疗效果,减轻患者临床症状,提升肺功能,降低炎症因子水平,改善免疫功能。
Objective To explore the therapeutic efficacy of Ginkgo biloba leaf extract injection in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary encephalopathy(PE).Methods A total of 88 AECOPD patients with PE,admitted to Puyang Traditional Chinese Medicine Hospital from April 2022 to June 2024,were selected as the study subjects.They were randomly divided into an observation group and a control group,with 44 patients in each group,using a random number table method.Patients in the control group received conventional treatment,while those in the observation group received treatment with Ginkgo biloba leaf extract injection in addition to the treatment in the control group.All patients were treated for 2 weeks.Before and after treatment,the chronic obstructive pulmonary disease score(CAT),Montreal Cognitive Assessment(MoCA)scores,pulmonary function indicators(forced vital capacity[FVC],forced expiratory volume in the first second[FEV1],and FEV1/FVC ratio),inflammatory factors(tumor necrosis factor-α[TNF-α],interleukin-8[IL-8],interleukin-6[IL-6]levels),immune function indicators(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))were compared between the two groups.The occurrence of adverse reactions during the treatment period was also compared between the groups.Results Before treatment,there were no statistically significant differences in CAT and MoCA scores between the two groups(P>0.05).After 2 weeks of treatment,the CAT score of the observation group was(20.03±1.74)points,significantly lower than(24.41±1.90)points of the control group,and the MoCA score was(27.11±2.46)points,significantly higher than(24.30±2.19)points of the control group,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in lung function indicators between the two groups(P>0.05).After 2 weeks of treatment,the lung function indicators of the observation group were significantly higher than those of the control group(P<0.05).Before treatment,there were no statistically significant differences in the levels of TNF-α,IL-8,and IL-6 between the two groups(P>0.05).After 2 weeks of treatment,the levels of TNF-α,IL-8,and IL-6 in the observation group were(13.36±2.38)pg/mL,(20.66±3.31)pg/mL,and(16.87±2.11)pg/mL,significantly lower than corresponding(18.74±3.34)pg/mL,(29.94±5.19)pg/mL,and(22.70±2.79)pg/mL in the control group(P<0.05).Before treatment,there were no statistically significant differences in CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)between the two groups(P>0.05).After 2 weeks of treatment,the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)levels in the observation group were significantly higher than those in the control group,while the CD8^(+)level was significantly lower than that in the control group,with all differences being statistically significant(P<0.05).During the treatment period,no significant adverse reactions were observed in either group.Conclusion Ginkgo biloba leaf extract injection can improve the clinical efficacy in patients with AECOPD combined with PE,alleviate clinical symptoms,enhance lung function,reduce the level of inflammatory factors,and improve immune function.
作者
黄敬蕊
王海明
王丁超
HUANG Jing-rui;WANG Hai-ming;WANG Ding-chao(Department of Intensive Care Medicine,Puyang Traditional Chinese Medicine Hospital,Puyang 457000,Henan,CHINA)
出处
《海南医学》
2025年第11期1540-1544,共5页
Hainan Medical Journal
基金
河南省医学科技攻关计划联合共建项目(编号:LHGJ20191092)。
关键词
慢性阻塞性肺疾病
肺性脑病
银杏叶提取物
肺功能
炎症因子
免疫功能
Chronic obstructive pulmonary disease
Pulmonary encephalopathy
Ginkgo biloba leaf extract
Lung function
Inflammatory factors
Immune function
