摘要
创伤后机体面临剧烈的内环境波动,包括炎症反应、氧化应激、代谢紊乱及细胞损伤等。近年来,细胞内源性保护机制在应对创伤应激、维持稳态及促进组织修复中的关键作用逐渐受到重视。本研究系统梳理创伤后细胞层面发生的主要病理变化,重点探讨免疫适应、线粒体稳态、自噬清除、抗氧化反应、热休克蛋白(HSPs)调控及脱氧核糖核酸(DNA)修复机制在损伤控制与再生过程中的作用,进一步分析这些内源性机制间的互作网络及其临床干预的靶点价值,结合最新研究进展提出多通路联合调控与个体化精准治疗可能成为未来创伤干预的核心方向,旨在为创伤修复的基础研究与转化应用提供理论依据和新策略。
Following trauma,the body undergoes profound internal disturbances,including inflammatory responses,oxidative stress,metabolic dysregulation and cellular injury.In recent years,increasing attention has been paid to the pivotal role of cellular endogenous protective mechanisms in responding to traumatic stress,maintaining homeostasis and promoting tissue repair.This review systematically summarizes the major pathological changes at the cellular level after trauma,with a focus on immune adaptation,mitochondrial homeostasis,autophagic clearance,antioxidant responses,heat shock proteins(HSPs)regulation,and DNA repair mechanisms in damage control and regeneration.Furthermore,the interactive networks among these endogenous pathways and their potential as clinical intervention targets are discussed.Based on the latest research advances,we propose that multi-pathway co-regulation and individualized precision therapy may represent key strategies for future trauma intervention,aiming to provide theoretical support and novel approaches for both basic research and the transformation and application in wound repair.
作者
秦启顺
王兴盛
武将
李楷
卢超
彭培
徐世红
秦煜宸
Qin Qishun;Wang Xingsheng;Wu Jiang;Li Kai;Lu Chao;Peng Pei;Xu Shihong;Qin Yuchen(School of Traditional Chinese Medicine Clinical Practice,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国急救医学》
2025年第6期502-510,共9页
Chinese Journal of Critical Care Medicine
关键词
创伤修复
内源性保护机制
氧化应激
自噬
免疫调控
Wound repair
Endogenous protective mechanisms
Oxidative stress
Autophagy
Immune regulation
