摘要
目的探讨腰痹通胶囊联合酮咯酸氨丁三醇治疗腰椎间盘突出症(LDH)患者的疗效,并分析其对腰椎功能、腰背肌活动度的影响。方法回顾性选取2020年06月~2023年06月本院80例LDH患者,依据治疗方案分为对照组、研究组,每组各40例。对照组给予酮咯酸氨丁三醇治疗,研究组给予腰痹通胶囊联合酮咯酸氨丁三醇治疗。统计对比两组临床疗效及治疗前后腰椎功能[日本骨科协会评估治疗分数(JOA)、Oswestry功能障碍指数(ODI)]、疼痛程度[视觉评分法(VAS)]、腰背肌活动度[后伸等长肌力(IMS)、后伸活动度(ROM)]、腰背伸肌群[平均肌电波幅(AEMG)、平均功率频率(MPF)、中位频率斜率(MFs)]、炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、氧化应激指标。比较两组不良反应发生情况。结果研究组总有效率高于对照组(90.00%比70.00%,P<0.05);与对照组比较,研究组治疗后JOA评分、IMS、ROM升高,ODI、VAS评分降低(P<0.05);与对照组比较,研究组治疗后AEMG、MPF升高,MFs绝对值降低(P<0.05);与对照组比较,研究组治疗后血清CRP、IL-6、TNF-α水平降低(P<0.05);与对照组比较,研究组治疗后血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平升高,丙二醛(MDA)水平降低(P<0.05);两组不良反应比较无明显差异(P>0.05)。结论腰痹通胶囊联合酮咯酸氨丁三醇治疗LDH的疗效确切,可促进腰椎功能、腰背肌活动度恢复,减轻疼痛程度,改善腰背伸肌群,抑制炎性-氧化应激反应,且具有一定安全性。
Objective Objective To investigate the efficacy of Yaobitong capsule combined with Ketorolac tromethamine in the treatment of patients with lumbar disc herniation(LDH),and to analyze its effect on lumbar function and lumbar dorsal muscle activity.Methods A total of 80 patients with LDH in our hospital from June 2020 to June 2023 were selected,and they were divided into control group and study group according to the treatment scheme,with 40 cases in each group.The control group was treated with Ketorolac tromethamine,and the study group was treated with Yaobitong capsule combined with ketorolac tromethamine.The clinical efficacy of the two groups was statistically compared,as well as the lumbar function[Japanese Orthopedic Association evaluated the treatment score(JOA),Oswestry disability index(ODI),and the degree of pain[visual analogue scale(VAS)],lumbar dorsal muscle activity[isometric muscle strength(IMS),Extension range of motion(ROM)],muscle group of lumbar and dorsal extensors[average EMG amplitude(AEMG),average power frequency(MPF),median frequency slope(MFS)],inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and oxidative stress indexes before and after treatment,and the adverse reactions of the two groups were also compared.Results The total effective rate of the study group was higher than that of the control group(90.00%vs 70.00%,P<0.05);compared with the control group,JOA score,IMS and ROM in the study group were increased after treatment,while the scores of ODI and VAS were decreased(P<0.05);compared with the control group,AEMG and MPF in the study group were increased after treatment,and the absolute value of MFS was decreased(P<0.05);compared with the control group,the levels of serum CRP,IL-6 and TNF-αin the study group were decreased after treatment(P<0.05);compared with the control group,the levels of serum superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in the study group were increased after treatment,while the level of malondialdehyde(MDA)was decreased(P<0.05);there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusions Yaobitong capsule combined with Ketorolac tromethamine is effective in the treatment of LDH,which can promote the recovery of lumbar function and lumbar dorsal muscle activity,reduce the degree of pain,improve the lumbar back extensor muscle group,inhibit inflammatory oxidative stress reaction,and has certain safety.
作者
李雅楠
王鹏飞
LI Yanan;WANG Pengfei(Beijing University of Traditional Chinese Medicine Dongzhimen Hospital Luoyang Hospital(Luoyang Traditional Chinese Medicine Hospital)Orthopedics and Traumatology Department Luoyang 471000,Henan Province)
出处
《航空航天医学杂志》
2025年第6期643-646,共4页
Journal of Aerospace medicine
关键词
腰椎间盘突出症
腰痹通胶囊
酮咯酸氨丁三醇
疗效
腰椎功能
Lumbar disc herniation
Yaobitong capsule
Ketorolac tromethamine
Curative effect
Lumbar function
