摘要
目的:探索甲状腺相关眼病的常见证候分布特征,为中医辨证论治提供依据。方法:采集河南中医药大学第一附属医院甲状腺相关眼病患者的四诊信息,建立数据库。运用Lantern 5.0软件构建隐结构模型,通过综合聚类分析甲状腺相关眼病的常见证候。采用SPSS 25.0统计软件进行因子分析和系统聚类分析,推测甲状腺相关眼病的证候。综合分析确定甲状腺相关眼病的证候分类。结果:共纳入621例甲状腺相关眼病患者,94个症状。纳入分析频次≥41的55个症状构建隐结构模型,得到20个隐变量,综合聚类得到6种常见证候。将频率≥6%的症状进行因子分析,得到19个公因子,用公因子进行系统聚类分析,推断出8个常见证候。综合2种分析方法和专业知识最终确定6种常见证候。结论:甲状腺相关眼病常见证候为肝胆湿热证、肝火旺盛证、肝郁气滞、心脾两虚证、气滞血瘀证、肝肾两虚证6种,可为甲状腺相关眼病的辨证治疗提供参考。
Objective:.To explore the common syndrome distribution characteristics in thyroid-associated ophthalmopathy(TAO) and provide a basis for syndrome differentiation and treatment in traditional Chinese medicine(TCM).Methods:Four-diagnosis information from patients with TAO at the First Affiliated Hospital of Henan University of Chinese Medicine was collected to establish a clinical database.A hidden structure model was constructed using Lantern 5.0 software,and comprehensive cluster analysis was performed to identify common syndromes of TAO.SPSS 25.0 software was used for factor analysis and hierarchical cluster analysis to infer potential syndrome types.Syndrome classification was finalized through integrated analysis.Results:A total of 621 TAO patients and 94 symptoms were included.Fifty-five symptoms with frequencies≥41 were used to construct a hidden structure model,yielding 20 hidden variables and 6 common syndromes via clustering.Nineteen common factors were extracted from factor analysis of symptoms with frequencies≥6%,and these common factors underwent hierarchical cluster analysis to infer eight common syndromes.By combining results from both analytical methods and expert knowledge,six common syndromes were ultimately identified.Conclusion:The six common syndromes of TAO are liver and gallbladder dampness-heat syndrome,liver fire hyperactivity syndrome,liver depression and qi stagnation syndrome,deficiency of the heart and spleen syndrome,qi stagnation and blood stasis syndrome,and deficiency of the liver and kidney syndrome.These findings can provide a reference for syndrome differentiation and treatment of TAO in TCM.
作者
李闪闪
符宇
王颖
魏丹丹
王婷
王菲
徐梦娇
金丽娜
燕树勋
LI Shanshan;FU Yu;WANG Ying;WEI Dandan;WANG Ting;WANG Fei;XU Mengjiao;JIN Lina;YAN Shuxun(Endocrinology Department of The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Scientific Research Department of The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Geriatrics of The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Postgraduate Studies of The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《世界中医药》
北大核心
2025年第6期975-983,共9页
World Chinese Medicine
基金
国家自然科学基金项目(U1204824)
全国老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)
河南省中医药科学研究专项(20-21ZY1016)
河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才项目(CZ0237-02)。
关键词
甲状腺相关眼病
隐结构模型
因子分析
系统聚类分析
综合聚类
证候
临床特征
辨证治疗
Thyroid-associated ophthalmopathy
Hidden structure model
Factor analysis
Hierarchical cluster analysis
Comprehensive clustering
Syndrome
Clinical features
Treatment based on syndrome differentiation
