摘要
“少阳主骨”理论源于《黄帝内经》,从经络、脏腑等多个角度阐述了“少阳”与“骨”的关系,是除“肾主骨”之外临床诊疗慢性筋骨病的又一指导思想。通过对近年来“少阳主骨”相关研究进行综述,发现“少阳主骨”理论指导下中医内外治法治疗慢性筋骨病疗效显著。同时,生物学机制研究表明中药复方可通过降低炎症介质水平、抑制血管翳形成、介导骨转换相关通路、干预细胞衰老凋亡等方式治疗少阳所主之骨病。此外,结合肝性骨病发病机制研究,发现“肝-骨轴”与“少阳主骨”的理论内涵一致,基于此提出从“肝-骨轴”角度研究“少阳主骨”相关机制的新设想。
The theory of “Shaoyang dominating the bone” originates from the Huangdi′s Internal Classic(Huang Di Nei Jing) and elaborates the relationship between Shaoyang and bones from multiple perspectives,including meridians,collaterals,and Zang-fu organs.It serves as an important guiding principle in the clinical treatment of chronic musculoskeletal diseases,in addition to the well-known theory that “kidneys governing the bone”.A review of recent studies on the “Shaoyang dominating the bone” theory reveals that traditional Chinese medicine(TCM) treatments,both internal and external,guided by this theory,show significant efficacy in treating chronic musculoskeletal disorders.Additionally,biological mechanism studies indicate that Chinese medicine compound formulas can treat bone diseases governed by Shaoyang by reducing inflammatory mediators,inhibiting vascular plaque formation,modulating bone turnover pathways,and intervening in cell aging and apoptosis.Furthermore,research on the pathogenesis of liver-related bone diseases reveals that the concept of the “liver-bone axis” aligns with the theoretical framework of “Shaoyang dominating the bone”.Based on this,a new perspective is proposed,suggesting further research on the mechanisms of “Shaoyang dominating the bone” from the viewpoint of the “liver-bone axis”.
作者
李知鑫
司誉豪
郭杨
刘孟敏
马勇
LI Zhixin;SI Yuhao;GUO Yang;LIU Mengmin;MA Yong(New Technology on Trauma Repairment and Reconstruction Laboratory,Nanjing University of Chinese Medicine,Nanjing 210023,China;The First School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Acupuncture-Moxibustion and Tuina,School of Health Preservation and Rehabilitation,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Traditional Chinese Medicine Clinical Innovation Center of Degenerative Bone&Joint Disease,Nanjing 210023,China;School of Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《世界中医药》
北大核心
2025年第5期856-859,866,共5页
World Chinese Medicine
基金
国家自然科学基金青年科学基金项目(82305268)
国家中医药管理局高水平中医药重点学科建设项目(国中医药人教函[2023]85号)
江苏省自然科学基金面上项目(BK20211300)。
关键词
少阳主骨
枢机不利
和解少阳
慢性筋骨病
骨质疏松症
骨关节炎
类风湿关节炎
肝-骨轴
Shaoyang dominating the bone
Pivot dysfunction
Harmonizing Shaoyang
Chronic musculoskeletal diseases
Osteoporosis
Osteoarthritis
Rheumatoid arthritis
Liver-bone axis
