摘要
孤独症谱系障碍(孤独症)已成为世界范围内神经发育障碍性疾病的难题之一,其发病率位居我国各类精神疾病之首。孤独症患儿普遍存在胃肠病症状及肠道菌群失调,且与患儿精神行为紊乱严重程度密切相关。肠道菌群通过肠-脑轴与精神类疾病产生相互作用,调节肠道微生物可能是防治孤独症的重要靶点。小儿推拿作为一种传统中医疗法,对小儿的消化道内微生物功能失调有显著的效果,对精神、神经系统疾患也有突出的疗效。基于现有研究结果,从推拿调节胃肠功能出发,探讨小儿推拿从肠治脑的可能性,为推拿疗法干预孤独症提供理论依据。
Autism spectrum disorder(ASD) has become one of the major challenges in the field of neurodevelopmental disorders globally,with its incidence ranking first among various mental health conditions in China.Children with ASD commonly exhibit gastrointestinal symptoms and gut microbiota imbalances,which are closely related to the severity of their behavioral and psychological disorders.The gut microbiota,through the gut-brain axis,interacts with mental health diseases,and regulating the gut microbiome could be a key target for the prevention and treatment of ASD.Pediatric Tuina,a traditional Chinese medicine(TCM) therapy,has shown significant effects in improving gastrointestinal microbial imbalances in children and has also demonstrated remarkable therapeutic outcomes for mental and neurological disorders.Based on existing research,this article explores the potential of pediatric Tuina in treating ASD through the mechanism of “treating the brain via the gut” by regulating gastrointestinal function,providing theoretical support for Tuina therapy as an intervention for ASD.
作者
易惺钱
王立
陈晓凡
黄敬滢
曾思瑶
朱卫娜
刘英
YI Xingqian;WANG Li;CHEN Xiaofan;HUANG Jingying;ZENG Siyao;ZHU Weina;LIU Ying(Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China;Nanchang Medicine College,Nanchang 330004,China;Jiangxi University of Chinese Medicine,Nanchang 330006,China)
出处
《世界中医药》
北大核心
2025年第5期791-796,共6页
World Chinese Medicine
基金
国家自然科学基金项目(82260857)
江西省卫生健康委员会科技计划项目(202210768)
江西省中医药管理局科技计划项目(2023A0034)
2022年度江西省(省直单位)名老中医药专家学术经验继承工作项目(赣财社指[2022]81号)。
关键词
肠道菌群
脑-肠轴
肠-脑互通
孤独症谱系障碍
小儿推拿
从肠治脑
胃肠症状
神经发育障碍性疾病
Gut microbiota
Brain-gut axis
Gut-brain interaction
Autism spectrum disorder
Pediatric Tuina
Treating the Brain from the gut
Gastrointestinal symptoms
Neurodevelopmental disorders
