摘要
过敏性哮喘是一种常见的疾病,严重影响患者的健康和日常生活。目前,治疗过敏性哮喘的主要手段是通过吸入激素类药物来控制其症状。近年来,随着对“肠-肺轴”的深入研究,人们逐渐认识到肠道微生物在肺部免疫功能调节中扮演着关键的角色。本文综述了肠道菌群对过敏性哮喘进展的影响,并深入探讨了益生菌及其代谢产物在过敏性哮喘治疗中的应用潜力和发展前景,希望为后续研究提供有益参考,以期推动过敏性哮喘临床治疗的进步。
Allergic asthma is a common condition that has a significant impact on the daily lives and overall well-being of patients.The current standard of care primarily involves the use of inhaled hormone medications to alleviate symptoms.However,recent research has shifted its focus towards understanding the immune system's role in the development of asthma pathogenesis,highlighting the crucial influence of intestinal microorganisms within the"gut-lung axis".This article delves into the intricate mechanisms by which intestinal flora regulates allergic asthma,including its effects on the intestinal barrier,involvement in inflammatory processes within the intestinal mucosal immune system,and modulation of immune cells.Furthermore,a comprehensive review of current clinical research on probiotics and bacterial lysates is presented,aiming to provide valuable insights and impetus for future investigations into the treatment and management of allergic asthma.
作者
申圳
郭慧慧
郭运丹
杨丽敏
高天乐
韩燕星
SHEN Zhen;GUO Huihui;GUO Yundan;YANG Limin;GAO Tianle;HAN Yanxing
出处
《中国医药生物技术》
2025年第3期306-312,共7页
Chinese Medicinal Biotechnology
基金
国家自然科学基金(82374061)
中国医学科学院医学与健康科技创新工程(2022-I2M-1-016)
北京市科技新星计划(20230484467)。
关键词
过敏性哮喘
肠-肺轴
肠道菌群
益生菌
allergic asthma
gut-lung axis
intestinal flora
probiotic
