摘要
肝脏与脾脏作为机体的重要器官,不仅独立执行各自生理功能,还通过相互作用共同维持机体的内环境稳态。本文综述了肝-脾轴作为整合代谢、循环、免疫和神经功能的关键生理轴线,在多种疾病发生发展中的作用机制及临床应用前景。通过总结最新研究进展,探讨肝-脾轴在代谢性疾病、感染性疾病、自身免疫性疾病和肿瘤等病理状态下的功能性联系,旨在为相关疾病的预防和治疗提供新的见解和思路。
As important organs in the body,the liver and spleen not only carry out their respective physiological functions but also work together to maintain internal environment homeostasis through their interactions.This review comprehensively summarizes the liver-spleen axis,a critical physiological network that integrates metabolism,circulation,immunity and neurological functions.It explores the mechanisms of action and clinical application prospects of the liver-spleen axis in the pathogenesis and progression of various diseases.By summarizing the latest research advancements,this review discusses the functional connections of the liver-spleen axis in pathological states such as metabolic disorders,infectious diseases,autoimmune conditions,and cancers.The aim is to provide novel insights for the prevention and treatment of related diseases.
作者
刘持录
王玉红
蒋建东
LIU Chilu;WANG Yuhong;JIANG Jiandong
出处
《中国医药生物技术》
2025年第3期290-296,共7页
Chinese Medicinal Biotechnology
基金
北京市自然科学基金-大兴创新联合基金(L246027)。
关键词
肝-脾轴
疾病机制
免疫调节
临床应用
liver-spleen axis
disease mechanisms
immune regulation
clinical application
