摘要
提出一种在无过渡金属催化剂的条件下,以乙二醇作为C1合成子,高效构建喹唑啉-4(3H)-酮的方法。该方法采用过硫酸钠作为氧化剂,以廉价易得的乙二醇和邻氨基苯甲酰胺为反应底物,在空气氛围下于100℃反应12 h,能以43%~90%的分离产率获得目标产物喹唑啉-4(3H)-酮类化合物。同时,对该氧化体系进行机理研究,并通过控制实验推测其反应机理。该反应使用商业化原料作为底物,反应条件简单,成本低廉,底物适用范围广。
A method for effectively constructing quinazolin-4(3H)-ones using ethylene glycol as a C1 synthon under transition-metal-free conditions has been developed.In this developed method,sodium persulfate serves as the oxidant,and readily available ethylene glycol and 2-aminobenzamides react under air at 100℃for 12 h,affording quinazolin-4(3H)-one derivatives in 43%~90%isolated yields.Mechanistic studies were conducted on this oxidative system,and control experiments were performed to propose a plausible reaction mechanism.This protocol employs commercially available starting materials,features simple reaction conditions,low cost,and broad substrate compatibility.
作者
吴际伟
李俊杰
柏汪恒
陈厚霖
许涛
周慧乔
WU Jiwei;LI Junjie;BAI Wangheng;CHEN Houlin;XU Tao;ZHOU Huiqiao(College of Chemistry and Materials Engineering,Anhui Science and Technology University,Bengbu 233030,China)
出处
《湖州师范学院学报》
2025年第4期33-41,共9页
Journal of Huzhou University
基金
安徽省高等学校科学研究重点项目(2024AH050319)
安徽省大学生创新创业训练计划项目(S202410879101)
南京博衢化工有限公司横向项目(881527)。
