摘要
合成了一种具有声敏活性的红色荧光碳点(CDs),将乏氧激活化疗药物AQ4N与CDs通过静电相互作用、氢键和π-π相互作用组装,制备了CDs@AQ4N纳米组装体.CDs@AQ4N在超声辐照下可有效产生单线态氧(^(1)O_(2))用于声动力治疗(SDT).SDT过程消耗肿瘤内氧气进一步加剧了肿瘤乏氧,从而激活AQ4N,将其转化为具有细胞毒性的AQ4,在小鼠肿瘤模型下实现了荧光成像指导下的SDT联合化疗.小鼠主要器官切片、血常规和血液生化分析结果均证实CDs@AQ4N具有优异的生物安全性.
A red fluorescent carbon dots(CDs)with sonodynamic activity were synthesized,and the CDs@AQ4N nano-assemblies were prepared by assembling the hypoxia-activating drug AQ4N,with CDs via electrostatic interaction,hydrogen bonding,andπ-πinteractions.CDs@AQ4N could effectively generate singlet oxygen(^(1)O_(2))for sonodynamic therapy(SDT)of cancer cells.Moreover,the depletion of intra-tumor oxygen during SDT further exacerbated the tumor hypoxia,which activated AQ4N and converted it into cytotoxic AQ4,enabling fluorescenceimaging-guided combination of SDT and chemotherapy for the treatment of mice tumors.The excellent biosafety of CDs@AQ4N was confirmed by mouse major organ sections,blood routine and blood biochemical analyses.
作者
庞娥
唐垣钰
赵少静
程强
王晨
陈健敏
蓝敏焕
PANG E;TANG Yuanyu;ZHAO Shaojing;CHENG Qiang;WANG Chen;CHEN Jianmin;LAN Minhuan(Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China;School of Pharmacy,Putian University,Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine,Fujian Province University,Putian 351100,China)
出处
《高等学校化学学报》
北大核心
2025年第6期92-102,共11页
Chemical Journal of Chinese Universities
基金
国家重点研发计划项目(批准号:2022YFA1207600)
国家自然科学基金(批准号:62375289,62175262)
湖南省重点研发计划项目(批准号:2022SK2101,2023NK2029)
福建省高校药物分析与检验医学重点实验室(莆田学院)开放课题(批准号:PALM 202201)的资助.
关键词
碳点
乏氧激活
声动力治疗
化疗
协同治疗
Carbon dots
Hypoxic activation
Sonodynamic therapy
Chemotherapy
Synergistic therapy
