摘要
Background and Objectives:Previous prospective studies have reported inconsistent findings on the association between obesity and mortality in patients with COVID-19.This study aimed to investigate the association between them by using a meta-analysis of prospective studies.Methods and Study Design:We searched PubMed and EMBASE to retrieve studies using keywords related to this topic on January 3,2022.Data were extracted for a random-effects meta-analysis to calculate a pooled odds ratio(OR),relative risk(RR),or hazard ratio(HR)with a 95%confidence interval(CI).Results:In the meta-analysis of 15 prospective cohort studies,obesity significantly increased the risk of mortality in patients with COVID-19(OR/RR/HR,1.52;95%CI,1.26 to 1.84;I2=90.4%).Most of the included studies were conducted in European(n=10)and North American(n=4)countries.In the subgroup meta-analysis by continent,there was a significant association between them in European countries(OR/RR/HR,1.78;95%CI,1.30 to 2.43;I2=81.4%).Also,in the subgroup meta-analysis by data source,obesity was significantly associated with the increased mortality in patients with COVID-19 in both populationand hospital-based data.Conclusions:We found that obesity is associated with the increased risk of mortality in patients of COVID-19.
