摘要
目的探讨四磨汤联合泮托拉唑治疗胃食管反流的临床疗效,以及对患者负性情绪、脑肠肽的影响。方法选取湖北省监利市中医医院2020年7月至2023年7月收治的胃食管反流患者102例,按随机数字表法分为对照组和观察组,各51例。两组患者均予泮托拉唑,观察组患者加服四磨汤口服液。两组患者均连续治疗8周。结果观察组总有效率为92.16%,显著高于对照组的76.47%(P<0.05);治疗后,两组患者的胃食管动力学指标(食管蠕动收缩比、食管括约肌松弛率、食管括约肌压力)均显著高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05);两组患者的中医证候积分、抑郁自评量表(SDS)和汉密尔顿焦虑量表(HAMA)评分均显著低于治疗前,且观察组均显著低于对照组(P<0.05);两组患者的胃动素和胃泌素水平均显著高于治疗前(P<0.05),而血清中脑肠肽指标(缩胆囊素和血管活性肽)均显著低于治疗前(P<0.05),且观察组均显著优于对照组(P<0.05)。观察组和对照组患者不良反应发生率相当(13.73%比9.80%,P>0.05)。结论四磨汤联合泮托拉唑治疗胃食管反流的临床疗效较好,可改善患者的临床症状和胃食管动力学指标,缓解负性情绪,且安全性良好。
Objective To investigate the clinical efficacy of Simotang Oral Liquid combined with pantoprazole in the treatment of gastroesophageal reflux,and its effect on negative emotions and brain-gut peptides in patients.Methods A total of 102 patients with gastroesophageal reflux admitted to the Jianli Hospital of Traditional Chinese Medicine from July 2020 to July 2023 were selected and divided into the control group and the observation group by the random number table method,with 51 cases in each group.The patients in the two groups were treated with pantoprazole,on this basis,the patients in the observation group were treated with Simotang Oral Liquid.Both groups were treated continuously for eight weeks.Results The total effective rate in the observation group was 92.16%,which was significantly higher than 76.47%in the control group(P<0.05).After treatment,the gastroesophageal motility indexes(esophageal peristalsis contraction ratio,esophageal sphincter relaxation rate,esophageal sphincter pressure)in the two groups were significantly higher than those before treatment(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The traditional Chinese medicine(TCM)syndrome scores,Self-Rating Depression Scale(SDS),and Hamilton Anxiety Scale(HAMA)scores in the two groups were significantly lower than those before treatment,and those in the observation group were significantly lower than those in the control group(P<0.05).The levels of motilin(MTL)and gastrin(GAS)in the two groups were significantly higher than those before treatment,while the levels of serum brain-gut peptide indexes[cholecystokinin(CCK)and vasoactive peptide(VIP)]in the two groups were significantly lower than those before treatment,and those in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group was comparable(13.73%vs.9.80%,P>0.05).Conclusion Simotang Oral Liquid combined with pantoprazole has good clinical efficacy and safety in the treatment of gastroesophageal reflux,which can improve clinical symptoms and gastroesophageal motility indexes,and alleviate negative emotions.
作者
李康宁
费良
张赢
LI Kangning;FEI Liang;ZHANG Ying(Jianli Hospital of Traditional Chinese Medicine,Jingzhou,Hubei,China 433300;Jianli People′s Hospital,Jingzhou,Hubei,China 433300)
出处
《中国药业》
2025年第11期88-91,共4页
China Pharmaceuticals
基金
湖北省卫生健康委员会联合基金项目[WJ2020H513]。
关键词
四磨汤
泮托拉唑
胃食管反流
负性情绪
脑肠肽指标
临床疗效
Simotang Oral Liquid
pantoprazole
gastroesophageal reflux
negative emotions
brain-gut peptide indexes
clinical efficacy
