摘要
目的本研究采用孟德尔随机化分析方法探索饮食习惯与系统性红斑狼疮(SLE)之间的因果关系。方法从MRC-IEU数据库获取“从不吃奶制品”“从不吃鸡蛋或含有鸡蛋的食物”“从不吃糖或含糖的食物/饮料”“从不吃小麦产品”“以上所有都吃”5种饮食习惯的全基因组关联研究数据作为暴露因素的工具变量。从MRC-IEU数据库获取SLE相关汇总数据作为发现队列(被记录为MSLE),使用来自芬兰数据库的SLE相关汇总数据作为验证队列(被记录为FSLE)。采用逆方差加权法(IVW)、MR-Egger法、加权中位数法、Simple Mode法、Weighted Mode法进行两样本孟德尔随机化分析探讨饮食习惯与SLE之间的因果联系。执行MREgger截距检验判断是否存在水平多效性,采用留一法验证结果的稳定性,Cochran’s Q检验和漏斗图评估异质性。结果孟德尔随机化分析显示,不吃小麦产品增加SLE发病风险(IVW:P<0.05)。而不吃奶制品、鸡蛋或含有鸡蛋的食物和以上所有都吃与SLE无明显因果关系(IVW:P>0.05)。不吃糖或含糖的食物/饮料与MSLE无明显因果关系(IVW:P=0.877),但与FSLE可能存在因果关联(IVW:P=0.016)。MR-Egger截距检验表明不存在水平多效性(P>0.05)。结论从不吃小麦产品可能是SLE的独立危险因素。但从不吃糖或含糖的食物/饮料与SLE的因果关系尚不能确定。
Objective This study employs Mendelian randomization analysis to explore the causal relationship between dietary habits and systemic lupus erythematosus(SLE).Methods We obtained data from the MRC-IEU database on five dietary habits as instrumental variables for exposure"never eating dairy products""never eating eggs or foods containing eggs""never eating sugar or foods/drinks containing sugar""never eating wheat products"and"I eat all of the above".Summary data related to SLE were retrieved from the MRC-IEU database for the discovery cohort(designated as MSLE)and from a Finnish database for the validation cohort(recorded as FSLE).Two-sample Mendelian randomization analyses were conducted using inverse variance weighting(IVW),MR-Egger,weighted median,Simple Mode,and Weighted Mode methods to investigate the causal relationship between dietary habits and SLE.The MR-Egger intercept test was performed to assess the presence of horizontal pleiotropy,while the leave-one-out method was employed to verify the stability of the results,with Cochran’s Q test and funnel plots used to evaluate heterogeneity.Results Mendelian randomization analysis indicated that never eating wheat products increases the risk of developing SLE(IVW:P<0.05).In contrast,there was no significant causal relationship between the consumption of dairy products,eggs or foods containing eggs,or the consumption of all of the above with SLE(IVW:P>0.05).Additionally,there was no significant causal relationship between never sugar or foods/drinks containing sugar and MSLE(IVW:P=0.877),although a potential causal association with FSLE was suggested(IVW:P=0.016).The MR-Egger intercept test indicated no evidence of horizontal pleiotropy(P>0.05).Conclusion Never eating wheat products may be an independent risk factor for SLE.However,the causal relationship between never sugar or foods/drinks containing sugar and SLE remains indeterminate.
作者
袁红秀
曾洪
唐发娟
李熙鸿
YUAN Hongxiu;ZENG Hong;TANG Fajuan;LI Xihong(Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu 610041,P.R.China;Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu 610041,P.R.China;Department of Urology,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;Department of Emergency,West China Second University Hospital,Sichuan University,Chengdu,610041,P.R.China)
出处
《中国循证医学杂志》
北大核心
2025年第5期512-518,共7页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金(编号:82071353)
四川省科技厅重点研发项目(编号:2021YFS0029)。
关键词
饮食习惯
系统性红斑狼疮
孟德尔随机化
全基因组关联研究
因果推断
Dietary habits
Systemic lupus erythematosus
Mendelian randomization analysis
Genome-wide association study
Causal inference
