摘要
副感染脑病是继发于系统性感染性疾病,特别是呼吸道病毒感染的一组急性脑病综合征。副感染性脑病不是由病毒直接侵袭中枢神经系统引起的,也不属于特异性的适应性免疫介导的自身免疫性脑炎,而是与细胞因子导致的炎性综合征和个体遗传因素等相关。副感染脑病的表型多样,或可初步归纳为11种表型。重症类型的病死率与致残率较高,及时确诊与积极的免疫治疗有助于改善疾病的预后。
Parainfectious encephalopathy is a group of acute encephalopathy syndromes secondary to systemic infectious diseases,especially respiratory virus infection.Parainfectious encephalopathy is not caused by direct invasion of the central nervous system by viruses,nor is it a specific autoimmune encephalitis mediated by adaptive immunity.It may be related to inflammatory syndromes caused by cytokine storms and individual genetic factors.Parainfectious encephalopathy has diverse clinical features,and it can be classified into 11 phenotypes.The mortality and disability rates of severe phenotypes are high.Timely diagnosis and immunotherapy can help improve prognosis.
作者
关鸿志
Guan Hongzhi(Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences)
出处
《中华神经科杂志》
北大核心
2025年第5期457-461,共5页
Chinese Journal of Neurology
基金
中央高水平医院临床科研业务经费资助项目(2022-PUMCH-B-120)。
关键词
感染
副感染脑病
呼吸道病毒
细胞因子
免疫治疗
Infection
Parainfectious encephalopathy
Respiratoryvirus
Cytokines
Immunotherapy
