摘要
Nonalcoholic fatty liver disease is a major contributor to chronic liver disease worldwide,and 10%-20%of nonalcoholic fatty liver progresses to nonalcoholic steatohepatitis(NASH).Astaxanthin is a kind of natural carotenoid,mainly derived from microorganisms and marine organisms.Due to its special chemical structure,astaxanthin has strong antioxidant activity and has become one of the hotspots of marine natural product research.Considering the unique chemical properties of astaxanthin and the complex pathogenic mechanism of NASH,astaxanthin is regarded as a significant drug for the prevention and treatment of NASH.Thus,this review comprehensively describes the mechanisms and the utility of astaxanthin in the prevention and treatment of NASH from seven aspects:antioxidative stress,inhibition of inflammation and promotion of M2 macrophage polarization,improvement in mitochondrial oxidative respiration,regulation of lipid metabolism,amelioration of insulin resistance,suppression of fibrosis,and liver tumor formation.Collectively,the goal of this work is to provide a beneficial reference for the application value and development prospect of astaxanthin in NASH.
基金
supported by Xinmiao Talents Program of Zhejiang Province granted to L.G(2019R413070)
Wenzhou Municipal Science and Technology Bureau granted to L.X.(Y20190049).
