摘要
Hepatocellular carcinoma(HCC)is a major cause of morbidity and mortality worldwide and the fastest-rising course of cancer-related death in the United States.In most instances,HCC emerges as a sequel to ongoing chronic hepatitis,occurring after the development of liver cirrhosis irrespective of its underlying etiology.However,patients with hepatitis b(HBV)-or hepatitis c virus-induced cirrhosis are at the highest risk for the development of HCC,with an annual incidence ranging from 0.5%to 10%^([1-3]).Non-alcoholic fatty liver disease(NAFLD),associated with diabetes mellitus and obesity,is now the most common liver disease and a major risk factor for HCC in developed countries.Although HCC can occur due to chronic HBV infection or NAFLD in the absence of cirrhosis(non-cirrhotic HCC),>90%of these patients also suffer from cirrhotic liver disease^([4,5]).
