摘要
内质网质量控制系统是维持细胞稳态的核心机制之一,主要通过内质网相关降解和内质网自噬两条途径介导内质网中错误折叠蛋白质的降解。三方基序蛋白13(tripartite motif 13,TRIM13)是一种定位于内质网膜上的蛋白,其E3泛素连接酶活性使其在内质网相关降解过程中发挥重要作用。此外,TRIM13也作为一种非经典内质网自噬受体介导内质网自噬的发生。近年来,TRIM13在内质网质量控制领域受到了广泛的关注,本文将对TRIM13的结构和功能以及TRIM13在内质网质量控制中的作用机制进行综述,并总结其在疾病中的异常表达和调控作用,以期为相关疾病的治疗提供新策略。
The endoplasmic reticulum quality control(ERQC)system is a core mechanism for maintaining cellular homeostasis,which primarily mediates the degradation of misfolded proteins in the endoplasmic reticulum(ER)through the ER-associated degradation(ERAD)and ER autophagy(ER-phagy)pathways.Tripartite motif 13(TRIM13)is a protein located on the ER membrane,which plays a critical role in ERAD via its E3 ubiquitin ligase activity.TRIM13 also acts as a non-classical ER-phagy receptor to mediate the occurrence of ER-phagy.TRIM13 has recently received extensive attention in the field of ERQC.Here we review the structure and function of TRIM13 and the mechanisms by which it contributes to ERQC,and summarize its abnormal expression and regulatory role in diseases,with the aim of providing new strategies for the treatment of related diseases.
作者
杨世英
戎玉莹
董玥宏
蒋丽娜
YANG Shiying;RONG Yuying;DONG Yuehong;JIANG Lina(Department of Immunlogy,College of Lab Medicine,Hebei North University,Zhangjiakou 075000;China.2.Institute of Microcirculation,Hebei North University,Zhangjiakou 075000)
出处
《中国比较医学杂志》
北大核心
2025年第4期159-168,共10页
Chinese Journal of Comparative Medicine
关键词
TRIM13
内质网质量控制
内质网相关降解
内质网自噬
tripartite motif 13
endoplasmic reticulum quality control
endoplasmic reticulum-associated degradation
endoplasmic reticulum autophagy
