摘要
泛素特异性蛋白酶7(USP7)是一种关键的去泛素化酶(DUBs),通过去除靶蛋白上的泛素链,阻止靶蛋白被蛋白酶体降解,从而维持其稳定性并调控多种生物学功能。USP7在肿瘤发生发展过程中发挥重要作用,可通过调控肿瘤细胞的增殖、凋亡、DNA损伤修复及免疫逃逸等关键机制,促进恶性肿瘤的进展和侵袭。本文综述了USP7在女性妇科肿瘤中的作用机制及研究进展,以期为妇科肿瘤的诊疗提供科学依据。
Ubiquitin-specific protease 7(USP7),a critical deubiquitinating enzyme(DUBs),regulates protein stability and diverse biological functions by removing ubiquitin chains from target substrates,thereby preventing their proteasomal degradation.USP7 plays a pivotal role in tumorigenesis and cancer progression by modulating key cellular processes,including tumor cell proliferation,apoptosis,DNA damage repair,and immune evasion,ultimately promoting malignant advancement and invasion.This review summarizes the mechanistic insights and recent advances in USP7's involvement in female gynecological malignancies,providing a scientific foundation for potential diagnostic and therapeutic strategies.
作者
邱浩文
刘瑶怡
胡灵娟
马虹露
周心怡
彭珍子
李国庆
QIU Haowen;LIU Yaoyi;HU Lingjuan;MA Honglu;ZHOU Xinyi;PENG Zhenzi;LI Guoqing(Institute of Cell Biology and Genetics,Basic Medical College,Hengyang Medical School,University of South China,Hengyang 421001,Hunan,China)
出处
《中南医学科学杂志》
2025年第3期383-387,共5页
Medical Science Journal of Central South China
基金
国家自然科学基金项目(82403497)
湖南省自然科学基金项目(2025JJ50541)。
关键词
USP7
妇科肿瘤
宫颈癌
卵巢癌
USP7
female gynecological malignancies
cervical cancer
ovarian cancer
