摘要
目的:探讨纤维蛋白原与白蛋白的比值(FAR)和纤维蛋白原与前白蛋白的比值(FPR)对结直肠癌的诊断价值。方法:选取2020年1月-2023年9月于我院行结直肠癌手术治疗的患者106例(结直肠癌组),同时期于我院住院治疗的结直肠良性疾病患者118例(结直肠良性疾病组)和肠镜检查未见明显异常的健康人群110例(健康对照组),运用统计学方法比较三组患者的FAR、FPR、NLR、CEA、CA19-9水平差异,比较检验结直肠癌组内FPR、FAR水平与其临床病理特征的相关性。用ROC曲线评价FAR、FPR、NLR、CEA、CA19-9对结直肠癌的诊断效能及其对结直肠癌与结直肠良性病变之间的鉴别诊断效能。结果:与结直肠良性疾病组患者和健康对照组的患者相比,结直肠癌组患者的术前NLR、FPR、FAR、CEA、CA19-9均显著升高(P<0.05);结直肠良性疾病组的FPR较健康对照组明显升高(P<0.05);FAR、NLR、CEA、CA19-9在两组间比较差异无统计学意义(P>0.05)。随着结直肠癌分化程度降低、肿瘤直径增大,浸润深度的加深以及临床分期的增加,结直癌患者的FPR、FAR的中位数显著升高,与肿瘤的发生位置无关。ROC曲线分析结果显示,FPR对结直肠癌的诊断效能显著高于其他检验指标(P<0.05)。结论:FPR对结直肠癌有较高的诊断效能,对结直肠癌早期筛查或者诊断具有较高的参考价值。
Objective:To explore the diagnostic value of FAR and FPR in colorectal cancer.Methods:We selected the clinical data from January 2020 to September 2023 of 106 patients(colorectal cancer group)who underwent colorectal cancer surgery in Liaocheng Second People's Hospital,118 patients(colorectal benign disease group)who were hospitalized for colorectal benign diseases,and 110 healthy individuals(healthy control group)who did not show significant abnormalities during colonoscopy.And then we used statistical methods to compare the differences in FAR,FPR,NLR,CEA,and CA19-9 levels among three groups of patients,and to compare and test the correlation between FPR,FAR levels and their clinical and pathological characteristics within the colorectal cancer group.Evaluating the diagnostic efficacy ofFAR,FPR,NLR,CEA,and CA19-9 in colorectal cancer using ROC curves.The receiver operating characteristic curve was drawn to evaluat the diagnostic efficacy of FAR,FPR,NLR,CEA,and CA19-9 in colorectal cancer and in colorectal benign and malignant lesions.Results:The preoperative NLR,FPR,FAR,CEA,and CA19-9 levels in the colorectal cancer group were significantly higher than the patients of the benign colorectal disease group and healthy control group(P<0.05);The FPR between the benign colorectal disease group and the healthy control group was statistically significant difference,(P<0.05)while there was no statistically significant difference in FAR,NLR,CEA,and CA19-9 between the two groups(P>0.05)As the degree of differentiation of colorectal cancer decreases,the diameter of the tumor increases,the depth of infiltration deepens,and the clinical stage increases,the median FPR and FAR of colorectal cancer patients were significantly increased,regardless of the location of the tumor.The ROC curve analysis results showed that the FPR's diagnostic efficacy of for colorectal cancer was significantly higher than other indicators(P<0.05).Conclusion:FPR has high diagnostic efficacy in colorectal cancer and can be used as a diagnostic and monitoring indicator for colorectal cancer.
作者
于艳艳
孟雪勤
王扬
YU Yan-yan;MENG Xue-qin;WANG Yang(Laboratory Department of Liaocheng Second People's Hospital,Shandong Linqing 262600)
出处
《医学检验与临床》
2025年第4期25-29,共5页
Medical Laboratory Science and Clinics
关键词
结直肠癌
FAR
FPR
诊断价值
Colorectal cancer
Fibrinogen to albumin ratio
Fibrinogen to prealbumin ratio
Diagnostic value
