摘要
目的测量伴海马硬化性颞叶癫痫(TLE-HS)患者皮层及皮层下灰质的体积、皮层厚度和皮层表面积,分析其临床意义。方法共纳入101例TLE-HS患者(TLE-HS组)和同期体检的220例健康志愿对照组(HC)。所有受试者均进行MRI检查,获取其高分辨率3D-T1 MPRAGE结构像数据,采用Freesurfer软件并基于Aseg和DKT图谱进行分割和量化。使用一般线性模型(GLM),以年龄、性别、受教育程度和总颅内体积作为协变量,比较2组受试者形态学指标,通过Spearman相关分析有统计学差异的皮层下核团体积与病程的相关性。结果TLE-HS组左侧苍白球[(1959.48±248.76)mm^(3)]和右侧丘脑的体积明显缩小[(7398.25±1043.41)mm^(3)],右侧海马[(4131.69±785.72)mm^(3)]、杏仁核[(1858.13±360.08)mm^(3)]及大脑右半球皮层灰质[(237967.87±36128.67)mm^(3)]的体积显著增大,差异均有统计学意义(P<0.05)。TLE-HS组皮层厚度和皮层表面积异常主要表现在颞叶和额叶两个脑区。结论TLE-HS患者大脑皮质及皮层下结构的形态学改变,为深入理解TLE-HS的病理生理机制提供了重要的影像学证据。
Objective To measure the cortical and subcortical gray matter volume,cortical thickness and cortical surface area in temporal lobe epilepsy with hippocampal sclerosis(TLE-HS)patients,and to analyze the clinical significance of the differences.Methods A total of 101 TLE-HS patients(TLE-HS group)and 220 healthy volunteers(HC group)were enrolled.All subjects underwent MRI examination to obtain high-resolution 3D-T1 MPRAGE structural image data,which were segmented and quantified by Freesurfer software based on Aseg and DKT maps.The morphological parameters were compared between the two groups using the general linear model(GLM)with age,sex,education level and total intracranial volume as covariates.Spearman correlation analysis was used to analyze the correlation between the subcortical nucleus volume with difference and disease duration.Results The volumes of the left pallidum((1959.48±248.76)mm^(3))and the right thalamus((7398.25±1043.41)mm^(3))in the TLE-HS group were significantly reduced,while the volumes of the right hippocampus((4131.69±785.72)mm^(3)),amygdala((1858.13±360.08)mm^(3))and the cortical gray matter((237967.87±36128.67)mm^(3))in the right hemisphere were significantly increased(P<0.05).The abnormal cortical thickness and cortical surface area in the TLE-HS group were mainly manifested in the temporal lobe and frontal lobe.Conclusion The morphological changes of cerebral cortex and subcortical structures in TLE-HS patients provide important imaging evidence for further understanding the pathophysiological mechanism of TLE-HS.
作者
闫玲玲
罕迦尔别克·库锟
哈丽玛·马太提
王云玲
贾琳
YAN Lingling;Hanjiaerbieke Kukun;Halima Mataiti;WANG Yunling;JIA Lin(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《中国实用神经疾病杂志》
2025年第5期552-557,共6页
Chinese Journal of Practical Nervous Diseases
基金
新疆维吾尔自治区科技厅“天山英才”科技创新领军人才项目(编号:2023TSYCLJ0027)
新疆维吾尔自治区自然科学基金资助项目(编号:2022D01C774)
2022年度“青年科研启航”专项基金项目(编号:2022YFY-QKQN-86)。
关键词
颞叶癫痫
海马硬化
磁共振成像
灰质体积
皮层厚度
Temporal lobe epilepsy
Hippocampal sclerosis
Magnetic resonance imaging
Gray matter volume
Cortical thickness
