摘要
目的:探究血清N末端脑钠肽前体(NT-proBNP)、可溶性白细胞分化抗原14(sCD14)、血清淀粉样蛋白A(SAA)与慢性阻塞性肺疾病(COPD)患者肺功能的相关性及疾病诊断价值。方法:选择2022年5月—2024年5月九江市第一人民医院收治的150例COPD患者,根据病情进展分为稳定期组(n=58)和COPD急性加重期(AECOPD)组(n=92)。同时收集同期在本院接受体检的60例健康成年人作为对照组。比较三组血清NT-proBNP、sCD14、SAA水平和用力肺活量(forced vital capacity,FVC)、呼气峰值流量(peak expiratory flow,PEF)、第1秒用力呼气容积占用力肺活量比值(FEV_(1)/FVC)。通过Pearson相关系数和受试者操作特征(ROC)曲线分析NT-proBNP、sCD14、SAA与肺功能的相关性及在COPD中的诊断效能。结果:稳定期组、AECOPD组血清NT-proBNP、sCD14、SAA水平均较对照组高,且AECOPD组血清NT-proBNP、sCD14、SAA水平均较稳定期组高(P<0.05)。稳定期组、AECOPD组FVC、FEV_(1)/FVC、PEF均较对照组低,且AECOPD组FVC、FEV_(1)/FVC、PEF均较稳定期组低(P<0.05)。血清NT-proBNP、sCD14、SAA水平均与FVC、FEV_(1)/FVC、PEF呈负相关(P<0.05)。血清NT-proBNP、sCD14、SAA联合诊断COPD的AUC明显高于NT-proBNP、sCD14、SAA单一诊断(Z=2.827、3.023、3.848,P<0.05)。结论:NT-proBNP、sCD14、SAA在COPD患者血清中均呈高表达,且与疾病严重程度和肺功能指标呈负相关,三种指标联合检测具有较高的诊断价值,可用于患者病情评估。
Objective:To explore the correlation between serum N-terminal brain natriuretic peptide precursor(NT-proBNP),soluble leukocyte differentiation antigen 14(sCD14),serum amyloid A(SAA)and pulmonary function in patients with chronic obstructive pulmonary disease(COPD)and the diagnostic value of the disease.Method:A total of 150 COPD patients admitted to Jiujiang NO.1 People's Hospital from May 2022 to May 2024 were selected and divided into stable group(n=58)and acute exacerbation COPD(AECOPD)group(n=92)according to disease progression.Meanwhile,60 healthy adults who underwent physical examination in our hospital during the same period were collected as the control group.Serum levels of NT-proBNP,sCD14,SAA,forced vital capacity(FVC),peak expiratory flow(PEF)and forced expiratory volume in one second/forced vital capacity(FEV_(1)/FVC)were compared among the three groups.Pearson correlation coefficient and receiver operating characteristic(ROC)curve were used to analyze the correlation of NT-proBNP,sCD14 and SAA with lung function and their diagnostic efficacy in COPD.Result:The levels of serum NT-proBNP,sCD14 and SAA in stable group and AECOPD group were higher than those in control group,and the levels of serum NT-proBNP,sCD14 and SAA in AECOPD group were higher than those in stable group(P<0.05).FVC,FEV_(1)/FVC and PEF in stable group and AECOPD group were lower than those in control group,and FVC,FEV_(1)/FVC and PEF in AECOPD group were lower than those in stable group(P<0.05).The levels of serum NT-proBNP,sCD14 and SAA were negatively correlated with FVC,FEV_(1)/FVC and PEF(P<0.05).The AUC of serum NT-proBNP,sCD14 and SAA combined diagnosis of COPD was significantly higher than that of single diagnosis of NT-proBNP,sCD14 and SAA(Z=2.827,3.023,3.848,P<0.05).Conclusion:NT-proBNP,sCD14 and SAA were highly expressed in the serum of COPD patients,and were negatively correlated with the severity of the disease and pulmonary function indicators.The combined detection of the three indicators has high diagnostic value and can be used for the assessment of patients'disease conditions.
作者
成诚
潘玲
CHENG Cheng;PAN Ling(Department of Respiratory Medicine,Jiujiang NO.1 People's Hospital,Jiujiang 332005,China;不详)
出处
《中国医学创新》
2025年第14期145-149,共5页
Medical Innovation of China
基金
江西省卫健委科技计划项目(202210268)。
关键词
N末端脑钠肽前体
可溶性白细胞分化抗原14
血清淀粉样蛋白A
慢性阻塞性肺疾病
N-terminal brain natriuretic peptide precursor
Soluble leukocyte differentiation antigen 14
Serum amyloid A
Chronic obstructive pulmonary disease
