摘要
目的:探讨胸部CT平扫联合血清糖类抗原125(CA125)、细胞角蛋白19片段(Cyfra21-1)、鳞状细胞癌抗原(SCC)在非小细胞肺癌(NSCLC)诊断中的临床意义。方法:前瞻性选取2023年3月—2024年3月在九江市第一人民医院检查的70例疑似NSCLC患者为研究对象。根据病理学检查结果将患者分为良性病变组(n=16)及恶性病变组(n=54)。对比良性病变组及恶性病变组胸部CT平扫影像学特征。比较良性病变及不同临床分期患者CA125、Cyfra21-1、SCC水平。采用受试者操作特征(ROC)曲线分析胸部CT平扫联合血清CA125、Cyfra21-1、SCC诊断NSCLC的价值。结果:恶性病变组肿块>3 cm、空洞征、胸膜凹陷征、分叶征、肿块密度不均匀、肿块边缘不光滑占比均高于良性病变组,差异均有统计学意义(P<0.05)。Ⅳ期组血清CA125、Cyfra21-1、SCC水平均高于Ⅲ期组,Ⅲ期组均高于Ⅱ期组,Ⅱ期组均高于Ⅰ期组,Ⅰ期组均高于良性病变组,差异均有统计学意义(P<0.05)。NSCLC患者血清CA125、Cyfra21-1、SCC水平与临床分期均呈正相关(P<0.05)。ROC曲线显示,胸部CT平扫联合血清CA125、Cyfra21-1、SCC诊断NSCLC的AUC为0.953,特异度为0.905,敏感度为0.949,联合诊断优于单项诊断(P<0.05)。结论:胸部CT平扫联合血清CA125、Cyfra21-1、SCC水平诊断NSCLC具有较高价值。
Objective:To investigate the clinical significance of chest CT plain scan combined with serum carbohydrate antigen 125(CA125),cytokeratin 19 fragment(Cyfra21-1)and squamous cell carcinoma antigen(SCC)in the diagnosis of non-small cell lung cancer(NSCLC).Method:A total of 70 patients with suspected NSCLC who were examined in Jiujiang NO.1 People's Hospital from March 2023 to March 2024 were prospectively selected as the study objects.According to the pathological examination results,the patients were divided into benign lesion group(n=16)and malignant lesion group(n=54).The imaging features of chest CT plain scan were compared between benign lesion group and malignant lesion group.The levels of CA125,Cyfra21-1 and SCC in patients with benign lesions and different clinical stages were compared.Receiver operating characteristic(ROC)curve was used to analyze the value of chest CT plain scan combined with serum CA125,Cyfra21-1 and SCC in the diagnosis of NSCLC.Result:The proportions of mass>3 cm,cavity sign,pleural indentation sign,lobulation sign,uneven mass density and unsmooth mass edge in malignant lesion group were higher than those in benign lesion group,the differences were statistically significant(P<0.05).The levels of serum CA125,Cyfra21-1 and SCC in stageⅣgroup were higher than those in stageⅢgroup,those in stageⅢgroup were higher than those in stageⅡgroup,those in stageⅡgroup were higher than those in stageⅠgroup,and those in stageⅠgroup were higher than those in benign lesion group,the differences were statistically significant(P<0.05).Serum CA125,Cyfra21-1 and SCC levels were positively correlated with clinical stage in NSCLC patients(P<0.05).ROC curve showed that the AUC of chest CT plain scan combined with serum CA125,Cyfra21-1 and SCC in the diagnosis of NSCLC was 0.953,the specificity was 0.905,and the sensitivity was 0.949,the combined diagnosis was superior to single diagnosis(P<0.05).Conclusion:Chest CT plain scan combined with serum CA125,Cyfra21-1 and SCC levels has a high value in the diagnosis of NSCLC.
作者
吴铭
胡俊松
WU Ming;HU Junsong(Department of Imaging Center,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China;不详)
出处
《中国医学创新》
2025年第15期96-100,共5页
Medical Innovation of China
基金
九江市指导性科技计划项目(S2023ZDYFN652)。
