摘要
目的:探讨黄连温胆汤联合针刺法治疗痰热腑实型缺血性脑卒中恢复期患者睡眠障碍的效果,并分析针药并用对改善患者认知功能的作用。方法:选取2020年4月—2023年4月北京中医药大学东直门医院收治的220例痰热腑实型缺血性脑卒中恢复期睡眠障碍患者作为研究对象,采用随机对照法分为对照组和试验组,各110例。对照组行常规西医治疗,试验组行黄连温胆汤结合针刺治疗。比较两组治疗效果、症状积分、睡眠质量、认知功能。结果:治疗12周后,试验组主症积分、次症积分及总积分均低于对照组,差异均有统计学意义(P<0.05);治疗12周后,试验组阿森斯失眠量表(AIS)评分及同型半胱氨酸(HCY)均低于对照组,脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)、β-淀粉样蛋白_(1-42)(Aβ_(1-42))及蒙特利尔认知评估量表(MoCA)评分均高于对照组,差异均有统计学意义(P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:针对痰热腑实型缺血性脑卒中恢复期睡眠障碍患者,予以黄连温胆汤联合针刺治疗,可改善患者睡眠质量,改善其认知功能,减轻恢复期不适症状,提高临床疗效。
Objective:To explore the effect of Huanglian Wendan Decoction combined with acupuncture on patients with sleep disorder during recovery period of phlegm-heat and Fu-organ excess syndrome ischemic stroke,and analyze the effect of combination of acupuncture and medicine on improving patients'cognitive function.Method:A total of 220 patients with sleep disorders during the recovery period of phlegm-heat and Fu-organ excess syndrome ischemic stroke treated in Dongzhimen Hospital,Beijing University of Chinese Medicine from April 2020 to April 2023 were selected as the study objects,and they were divided into control group and experimental group by randomized control method,with 110 cases in each group.The control group received conventional western medicine treatment,the experimental group received Huanglian Wendan Decoction combined with acupuncture treatment.The treatment effect,symptom score,sleep quality and cognitive function were compared between the two groups.Result:After 12 weeks of treatment,the main disease score,secondary disease score and total score of experimental group were lower than those of control group,the differences were statistically significant(P<0.05).After 12 weeks of treatment,the scores of Athens insomnia scale(AIS)and homocysteine(HCY)in experimental group were lower than those in control group,and the score of brain-derived neurotrophic factor(BDNF),5-hydroxytryptophane(5-HT),β-amyloid_(1-42)(Aβ_(1-42))and Montreal cognitive assessment scale(MoCA)score in experimental group were higher than those in control group,the differences were statistically significant(P<0.05).The total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P<0.05).Conclusion:Huanglian Wendan Decoction combined with acupuncture can improve sleep quality,improve cognitive function,reduce discomfort symptoms and improve clinical efficacy in patients with sleep disorder during recovery period of phlegm-heat and Fu-organ excess syndrome ischemic stroke.
作者
周楠楠
ZHOU Nannan(Department of Brain Diseases,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 101121,China)
出处
《中国医学创新》
2025年第13期21-26,共6页
Medical Innovation of China
关键词
痰热腑实型
缺血性脑卒中
恢复期
睡眠障碍
黄连温胆汤
针刺
认知功能
Phlegm-heat and Fu-organ excess syndrome
Ischemic stroke
Recovery period Sleep disorders
Huanglian Wendan Decoction
Acupuncture
Cognitive function
