摘要
促渗剂能够增强药物活性成分穿透胃肠道上皮细胞层的能力,是提高口服吸收效率的重要策略。中药来源的促渗剂往往具有较长的人用历史,生物相容性良好、不良反应可控。该综述简要介绍了药物口服吸收的肠上皮屏障,分别介绍了中药来源的促渗剂促进小分子药物、大分子药物和纳米药物克服肠上皮屏障并促进药物口服吸收的研究进展,同时总结了中药来源促渗剂的促吸收效果和机制,以期为中药来源促渗剂的进一步挖掘和深入研究提供文献支持。
Permeation enhancers can enhance the penetration ability of active pharmaceutical ingredients through the epithelial cell layer of the gastrointestinal tract,which is an important strategy to enhance oral absorption eficiency.Permeation enhancers derived from traditional Chinese medicines often have a long history of human use,with good biocompatibility and manageable adverse reactions.This review provides an overview of the intestinal epithelial barrier to oral absorption of drugs and highlights the research progress of traditional Chinese medicine-derived permeation enhancers in promoting the oral absorption of small molecule drugs,macromolecular drugs,and nanomedicines by overcome this barrier.This review also summarizes the absorption promotion effects and mechanisms of traditional Chinese medicinederived permeation enhancers on the above drugs,aiming to provide literature support for further exploration and in-depth research on traditional Chinese medicine-derived permeation enhancers.
作者
姜雨彤
盛剑勇
陈明伟
王建新
李西林
JIANG Yutong;SHENG Jianyong;CHEN Mingwei;WANG Jianxin;LI Xilin(College of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203;Dept.of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203;Biopharma Industry Promotion Center Shanghai,Shanghai 201203)
出处
《中国医药工业杂志》
2025年第4期444-450,共7页
Chinese Journal of Pharmaceuticals
关键词
促渗剂
口服给药
吸收
药物配伍
纳米药物
研究进展
permeation enhancer
oral administration
absorption
compatibility of drugs
nanomedicine
research progress
