摘要
Dear Editor:Uveal melanoma(UM)is a deadly ocular cancer highly metastasizing to the liver.1 The vascular barrier in the eyes is critical in preventing UM metastasis.However,the mechanism by which melanoma escapes from the eyes is mainly unknown.Metastatic UM tumors are highly vascularized with leaky blood vessels due to excessive vascular endothelial growth factor(VEGF)production.2 Here,we discovered that UM cells with commonly found mutations(GNA11Q209L or GNAQQ209L)rely on VEGF to permeabilize the endothelial barrier and promote UM cell migration across the endothelium.
基金
supported by grants from the American Cancer Society Discovery Boost Grants(AHEAD-DBG-23-1156429-01-MM to KHY)
National Institute of Health(NIH)(R01EY029339 to KHY,K12EY021475 and K08EY034935 to DEM,and P30EY001792 to the Department of Ophthalmology&Visual Sciences).
