摘要
目的 分析武汉地区老年发热呼吸道症候群流行病学特征及季节性变化。方法 收集2021年1月至2023年12月武汉地区哨点医院老年发热呼吸道症候群病例标本468份,对标本进行多重实时荧光PCR检测,并对阳性结果进行分析。结果 老年发热呼吸道症候群病例标本468份中,检出阳性标本254份,总阳性率为54.27%,男性和女性标本阳性检出率比较差异无统计学意义(P>0.05)。468份标本中共检出21种病原体,其中检出率前5的病原体分别为肺炎链球菌132份(51.97%)、流感嗜血杆菌65份(25.59%)、流感病毒32份(12.60%)、呼吸道合胞病毒29份(11.42%)和鼻病毒19份(7.48%)。不同年龄、不同性别患者前5种病原体检出率比较差异无统计学意义(P>0.05)。2021至2023年前5种病原体检出率差异无统计学意义(P>0.05)。前5种病原体呈明显的周期性变化,以冬季检出率最高(P<0.05)。其中肺炎链球菌感染具有明显的季节性特点,冬季高发(P<0.05)。结论 武汉地区的老年发热呼吸道症候群感染以肺炎链球菌、流感嗜血杆菌、流感病毒、呼吸道合胞病毒及鼻病毒为主,感染高峰期是冬季。
Objective To analyze the epidemiological characteristics and seasonal variation of febrile respiratory syndrome(FRS) in the elderly in Wuhan area.Methods A total of 468 specimens were collected from elderly patients with FRS in the sentinel hospitals in Wuhan from January 2021 to December 2023.The specimens were detected by multiplex real-time PCR,and the positive results were analyzed.Results Of 468 samples from elderly patients with FRS,254 positive specimens were detected,and the total positive rate was 54.27%.There was no significant difference in the positive detection rate between male and female samples(P>0.05).A total of 21 pathogens were detected in 468 specimens,and the top 5 pathogens were Streptococcus pneumoniae(n=132,51.97%),Haemophilus influenzae(n=65,25.59%),influenza virus(n=32,12.60%),respiratory syncytial virus(n=29,11.42%) and rhinovirus(n=19,7.48%).There was no significant difference in the detection rates of the top 5 pathogens among patients with different ages and genders(P>0.05).There was no significant difference in the detection rate of the top 5 pathogens from 2021 to 2023(P>0.05).The top five pathogens showed obvious periodic changes,and the detection rate was the highest in winter(P<0.05).Among them,Streptococcus pneumoniae infection had obvious seasonal characteristics,with a high incidence in winter(P<0.05).Conclusion Streptococcus pneumoniae,Haemophilus influenzae,influenza virus,respiratory syncytial virus and rhinovirus are the main pathogens in elderly patients with FRS in Wuhan area,and the infection peak season is winter.
作者
李倩
魏婷
柳湘洁
刘晓霞
夏明
魏亮
梁丽媛
张丽萍
LI Qian;WEI Ting;LIU Xiangjie;LIU Xiaoxia;XIA Ming;WEI Liang;LIANG Liyuan;ZHANG Liping(Department of Geriatrics,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077,China;the First Department of Cardiovascular Diseases,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077,China;Department of Cardiology,the Fourth Hospital of Wuhan City,Wuhan 430030,China)
出处
《临床误诊误治》
2025年第9期71-76,共6页
Clinical Misdiagnosis & Mistherapy
基金
湖北省2023—2024年度中医药科研立项项目(ZY2023M021)。
关键词
发热呼吸道症候群
老年
流行情况
季节性
肺炎链球菌
流感嗜血杆菌
呼吸道合胞病毒
Febrile respiratory syndrome
Elderly
Prevalence of diseases
Seasonality
Streptococcus pneumoniae
Haemophilus influenzae
Respiratory syncytial virus
