摘要
Comprehensive Summary Herein,a[1,2]-phospha-Brook rearrangement-initiated palladium-catalyzed cyclization reaction for base-controlled selective synthesis of 2H-isoindole-1-carboxamide and 2H-isoindole-1-carbonitrile derivatives has been described.This strategy features double isocyanide insertion,efficient bond combinations,simple operation and reaction conditions.Mechanistic studies show that the[1,2]-phospha-Brook rearrangement is the key step in this reaction.This protocol offers a novel and concise strategy for the synthesis of 2H-isoindole derivatives.
基金
financially supported by the National Natural Science Foundation of China(22071063)
National Youth Talent Support Program,Guangdong Basic and Applied Basic Research Foundation(2021B1515020058 and 2024B1515040027)
Guangzhou Science and Technology Projects(2024A04J6248).
