摘要
允许性高碳酸血症(PHC)通气策略是以小潮气量为特征的肺保护性通气策略,不仅能够降低由肺损伤诱发的认知障碍的发生率,还可通过增加脑血流灌注、维持脑氧代谢平衡以及减轻神经元损伤等作用机制发挥脑保护作用,从而预防或治疗机械通气相关的认知功能障碍。现将PHC通气策略对机械通气患者认知功能的影响及其机制,以及PHC通气策略的临床应用进行综述,以期为机械通气患者的脑保护研究提供新思路。
Permissive hypercapnia(PHC)is a lung-protective ventilation strategy characterized by low tidal volumes.It not only reduces the incidence of cognitive impairment induced by lung injury but also exerts neuroprotective effects by increasing cerebral blood flow,maintaining cerebral oxygen metabolism balance and attenuating neuronal injury.These mechanisms collectively help prevent or treat cognitive dysfunction associated with mechanical ventilation.This article reviews the effects of PHC ventilation strategy on cognitive function in mechanically ventilated patients,its underlying mechanisms and its clinical applications,aiming to provide new insights for brain protection research in mechanically ventilated patients.
作者
李佩钰
黄敏
田毅
LI Peiyu;HUANG Min;TIAN Yi(Department of Anesthesiology,Haikou Affiliated Hospital of Central South University Xiangya School of Medicine,Haikou 570208,China)
出处
《陕西医学杂志》
2025年第5期716-720,共5页
Shaanxi Medical Journal
基金
国家自然科学基金资助项目(81660195)
海南省外国专家项目(G20230607012E)
海南省卫生健康行业科研项目(22A200301)。
关键词
允许性高碳酸血症
肺保护性通气策略
机械通气
认知功能
脑保护
Permissive hypercapnia
Lung-protective ventilation strategy
Mechanical ventilation
Cognitive function
Neuroprotection
