摘要
骨组织工程(bone tissue engineering,BTE)支架的成分、孔径、孔隙率、机械性能等对骨再生的影响已被广泛研究。然而,目前关于其多尺度结构设计影响骨再生的研究仍不充分。基于仿生技术的发展,通过模仿天然材料的多尺度结构来改善BTE支架的机械性能和生物学活性以促进骨再生,是一种有前景的策略。因此,本文综述了近年来仿生结构材料在BTE支架中的研究进展,并讨论了未来发展的机遇和挑战,旨在为设计出性能更优越的BTE支架提供灵感。
The influence of component composition,pore size,porosity,and mechanical properties of bone tissue engineering(BTE)scaffolds on bone regeneration has been extensively studied.However,there is currently a lack of research on the impact of multi-scale structural design on bone regeneration.With the advancement of biomimetic technology,mimicking the multiscale structures of natural materials presents a promising strategy to enhance the mechanical performance and biological activity of BTE scaffolds and facilitate bone regeneration.As such,this review provides a summary of recent advances in biomimetic structural materials utilized in BTE scaffolds,discussing future development opportunities and challenges with the aim of inspiring the design of BTE scaffolds with superior properties.
作者
王云
王佐林
WANG Yun;WANG Zuolin(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Oral Implantology,Shanghai Tongji Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)
出处
《口腔颌面外科杂志》
2025年第2期142-144,共3页
Journal of Oral and Maxillofacial Surgery
基金
国家重点研发计划(2018YFE0202202,2018YFE0202200)。
关键词
骨组织工程
骨组织工程支架
骨再生
仿生结构材料
bone tissue engineering
bone tissue engineering scaffolds
bone regeneration
biomimetic structural materials
