摘要
炎症性肠病(inflammatory bowel disease,IBD)是一种慢性炎症性疾病,目前病因尚不明确。间充质干细胞(mesenchymal stem cells,MSCs)及其外泌体(MSCs-exosomes,MSCs-EXO)因其具有免疫调节和促生存的特性,现已成为治疗IBD的一种新兴治疗方式。它们可以通过分泌多种抗炎因子来抑制炎症的发生,促进疾病的缓解。近年来也被广泛应用于临床。但其中许多机制尚不清楚,需要我们进一步探索和研究。因此本文就MSCs及MSCs-EXO在IBD中的作用机制及研究进展作一综述,供临床医师参考。
Inflammatory bowel disease(IBD)is a chronic inflammatory disease with an unclear etiology.Mesenchymal stem cells(MSCs)and their exosomes(MSCs-EXO)are now an emerging therapeutic modality for the treatment of IBD due to their immunomodulatory and pro-survival properties.They can inhibit inflammation and promote disease remission by secreting multiple anti-inflammatory factors.They have also been widely used in clinical practice in recent years.However,many of these mechanisms are still unclear and need to be further explored and investigated.Therefore,this article provided a review of the mechanism of action and research progress of MSCs and MSCs-EXO in IBD for clinicians′reference.
作者
王顺娜
伍杨
郑晓凤
于晓辉
张久聪
WANG Shunna;WU Yang;ZHENG Xiaofeng;YU Xiaohui;ZHANG Jiucong(Department of Gastroenterology,the 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050;The First Clinical College of Medicine,Gansu University of Traditional Chinese Medicine;Department of Gastroenterology,the Second Hospital of Lanzhou University,China)
出处
《胃肠病学和肝病学杂志》
2025年第3期443-447,452,共6页
Chinese Journal of Gastroenterology and Hepatology
基金
中央高校优秀青年团队培育项目(31920220065)
甘肃省卫生健康行业科研项目(GSWSKY2023-34)
第九四〇医院研究生导师专项课题(2023YXKY020)。
关键词
间充质干细胞
外泌体
治疗
炎症性肠病
研究进展
Mesenchymal stem cells
Exosomes
Treatment
Inflammatory bowel disease
Research progress
