摘要
胃食管反流病(gastroesophageal reflux disease,GERD)是一种常见的临床疾病,影响范围广,尽管目前认为其发病机制涉及食管下括约肌抗反流屏障结构与功能障碍、食管对反流物的清除功能异常以及食管黏膜屏障功能降低等,但由于影响GERD发生发展的重要因素众多,其确切的相关机制尚不明确,本文对影响GERD的重要因素及相关机制的研究进展进行综述。
Gastroesophageal reflux disease(GERD)is a prevalent clinical condition with far-reaching effects.It is currently understood that its pathogenesis involves structural abnormalities of the antireflux barrier at the lower esophageal sphincter,impaired clearance of reflux by the esophagus,and compromised mucosal barrier function.However,due to the multitude of significant factors influencing the onset and progression of GERD,the precise mechanisms remain unclear.This article reviewed the latest research on the key factors and associated mechanisms that impact GERD.
作者
李修业
方向明
LI Xiuye;FANG Xiangming(Department of Gastroenterology,Puren Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430081;Medical College,Wuhan University of Science and Technology,China)
出处
《胃肠病学和肝病学杂志》
2025年第3期420-423,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
中国金属学会冶金安全与健康分会健康卫生科研项目(jkws202319)。
关键词
胃食管反流病
性别
饮食
细胞因子
焦虑
抑郁
Gastroesophageal reflux disease
Gender
Diet
Cytokines
Anxiety
Depression
