摘要
We comment on an article published by Mansouri et al in the World Journal of Diabetes.L-arginine(L-Arg),a dietary supplement,is a precursor of nitric oxide,can improve cardiovascular disease,and it is important for treating heart disease and hypertension.Previous studies have demonstrated a beneficial effect of L-Arg on diabetes.In the study by Mansouri et al,L-Arg moderately increased blood glucose levels in normal rats.However,in diabetic rats,L-Arg significantly increased lipid levels,which is different from the findings of previous studies.This study demonstrated that a safe dose of 0.5 g/kg in diabetic rats can improve the lipid profile and decrease body weight.However,high doses(1 g/kg or higher)may aggravate damage to myocardial tissue in diabetic rats by increasing blood glucose,inflammation,and oxidative stress.Therefore,this study further demonstrated that high doses of L-Arg can exacerbate myocardial injury in diabetic patients.
基金
Supported by The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138
The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008
The Key Discipline of Zhejiang Province in Medical Technology(First Class,Category A)
The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003.
