摘要
目的检测胃癌组织葡萄糖转运蛋白1相关的长链非编码核糖核酸(LncRNA GAL)表达,并探讨其与临床病理特征、生存预后的关系。方法选取2019年1月至2020年10月在中国人民解放军联勤保障部队第989医院行根治术治疗的106例胃癌患者,均检测胃癌组织和癌旁正常组织LncRNA GAL表达,并比较不同临床病理特征患者胃癌组织LncRNA GAL表达。胃癌患者术后随访3年,将术后3年生存患者归为生存组,死亡患者归为死亡组。采用Cox回归分析法分析胃癌患者术后3年死亡的影响因素,并绘制Kaplan-Meier生存曲线分析胃癌组织LncRNA GAL不同表达患者的生存率。结果106例胃癌患者随访3年期间有4例剔除研究,剩余102例胃癌患者死亡率为31.37%(32/102);胃癌组织LncRNA GAL相对表达量高于癌旁正常组织(P<0.05);肿瘤直径<5 cm、中高分化、TNM分期Ⅰ~Ⅱ期、T_(1)~T_(2)期、无淋巴结转移、无脉管侵犯患者胃癌组织LncRNA GAL相对表达量均分别低于肿瘤直径≥5 cm、低分化、TNM分期Ⅲ期、T_(3)~T_(4)期、淋巴结转移、脉管侵犯患者(P<0.05);死亡组非肠型、低分化、TNM分期Ⅲ期、T_(3)~T_(4)期、淋巴结转移、脉管侵犯占比及胃癌组织LncRNA GAL相对表达量均高于生存组(P<0.05);低分化(RR=2.910,95%CI:1.333~6.349)、TNM分期Ⅲ期(RR=4.063,95%CI:1.933~8.540)、T_(3)~T_(4)期(R^R=2.675,95%CI:1.247~5.734)、淋巴结转移(RR=2.316,95%CI:1.117~4.802)、脉管侵犯(RR=3.142,95%CI:1.530~6.451)、胃癌组织LncRNA GAL相对表达量升高(RR=2.125,95%CI:1.297~3.482)是胃癌患者术后3年死亡的危险因素(P<0.05);胃癌组织LncRNA GAL高表达患者3年生存率低于低表达患者(P<0.05)。结论胃癌组织LncRNA GAL表达升高,与肿瘤直径、浸润程度、分化程度、临床分期、淋巴结转移、脉管侵犯均有关,是生存预后的影响因素。
【Objective】To detect the expression of glucose transporter 1 associated long chain noncoding ribonucleic acid(LncRNA GAL)in gastric cancer tissue,and explore its relationship with clinical pathological features and survival prognosis.【Methods】A total of 106 gastric cancer patients treated with radical surgery in the 989th Hospital of the PLA Joint Logistic Support Force from January 2019 to October 2020 were selected.The expression of LncRNA GAL in gastric cancer tissue and adjacent normal tissue was detected,and the expression of LncRNA GAL in gastric cancer tissue of patients with different clinical pathological characteristics was compared.All patients with gastric cancer were followed up for 3 years after surgery,and those who survived for 3 years were classified as the survival group,while those who died were classified as the death group.The influencing factors of 3-year postoperative death in gastric cancer patients were analyzed using Cox regression analysis method.The survival rate of patients with different expressions of LncRNA GAL in gastric cancer tissue was analyzed using Kaplan-Meier survival curve.【Results】During a 3-year follow-up period,4 out of 106 gastric cancer patients were excluded,and the remaining 102 gastric cancer patients had a mortality rate of 31.37%(32/102).The relative expression level of LncRNA GAL in gastric cancer tissue was higher than that in adjacent normal tissue(P<0.05).The relative expression levels of LncRNA GAL in gastric cancer tissues of patients with tumor diameter<5 cm,medium to high differentiation,TNM stage Ⅰ to Ⅱ,T1 to T2 stage,no lymph node metastasis,and no vascular invasion were lower than those of patients with tumor diameter≥5 cm,low differentiation,TNM stage Ⅲ,T3 to T4 stage,lymph node metastasis,and vascular invasion,respectively(P<0.05).The proportion of non-intestinal,poorly differentiated,TNM stage Ⅲ,T3 to T4 stage,lymph node metastasis,vascular invasion,and the relative expression of LncRNA GAL in gastric cancer tissue in the death group were higher than those in the survival group(P<0.05).Low differentiation(RR=2.910,95%CI:1.333 to 6.349),TNM stage Ⅲ(RR=4.063,95%CI:1.933 to 8.540),T3 to T4 stage(RR=2.675,95%CI:1.247 to 5.734),lymph node metastasis(RR=2.316,95%CI:1.117 to 4.802),vascular invasion(RR=3.142,95%CI:1.530 to 6.451),and increased relative expression of LncRNA GAL in gastric cancer tissue(RR=2.125,95%CI:1.297 to 3.482)were risk factors for postoperative 3-year mortality in gastric cancer patients(P<0.05).Compared with patients with low expression of LncRNA GAL in gastric cancer tissue,the patients with high expression of LncRNA GAL in gastric cancer tissue had a lower 3-year survival rate(P<0.05).【Conclusion】The expression of LncRNA GAL in gastric cancer tissue is elevated,and it is related to tumor diameter,infiltration degree,differentiation degree,clinical stage,lymph node metastasis,and vascular invasion,and it is a factor affecting survival prognosis.
作者
宁琳琳
郑国宝
王小利
NING Linlin;ZHENG Guobao;WANG Xiaoli(Department of Oncology,the 989th Hospital of the PLA Joint Logistic Support Force,Luoyang,Henan 471100,China)
出处
《中国医学工程》
2025年第4期37-42,共6页
China Medical Engineering
关键词
胃癌
临床病理特征
生存预后
长链非编码核糖核酸
葡萄糖转运蛋白1
gastric cancer
clinical pathological features
survival prognosis
long chain noncoding ribonucleic acid
glucose transporter 1
