摘要
高分辨率计算机断层扫描(high-resolution computed tomography,HRCT)作为结缔组织病相关间质性肺病(connective tissue disease-interstitial lung disease,CTD-ILD)诊断的“金标准”,由于存在辐射暴露问题,在疾病长期动态监测中的应用受到了限制。磁共振成像(magnetic resonance imaging,MRI)作为一种无辐射、多参数成像技术,能够提供肺部通气、灌注、组织硬度和生物力学特性的定量信息,无创性地评估CTD-ILD的病理变化和疾病进展。本文系统综述了MRI在CTD-ILD中的应用现状,重点分析了超短回波序列(ultrashort echo time,UTE)、磁共振弹性成像(magnetic resonance elastography,MRE)、动态对比增强MRI(dynamic contrast-enhanced magnetic resonance imaging,DCE-MRI)及超极化^(129)Xe MRI(hyperpolarized^(129)Xe magnetic resonance imaging,HP^(129)Xe MRI)等技术在CTD-ILD诊断、分型及疗效评估中的潜力,并探讨了当前技术局限性与未来发展方向,以期为优化CTD-ILD的临床管理提供新思路。
High-resolution computed tomography (HRCT),regarded as the"gold standard"for the diagnosis of connective tissue disease-interstitial lung disease (CTD-ILD),due to the problem of radiation exposure,its application in the long-term dynamic monitoring of diseases is restricted.Magnetic resonance imaging (MRI),a non-radiation and multi-parameter imaging technology,can provide quantitative information on lung ventilation,perfusion,tissue hardness,and biomechanical properties.It enables the non-invasive assessment of pathological changes and disease progression in CTD-ILD.This article systematically reviews the current application status of MRI in CTD-ILD.It focuses on analyzing the potential of techniques such as ultrashort echo time (UTE),Magnetic resonance elastography (MRE),dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI),and hyperpolarized ^(129)Xe magnetic resonance imaging (HP ^(129)Xe MRI) in the diagnosis,classification,and efficacy evaluation of CTD-ILD.Moreover,it explores the limitations of current technologies and future development directions,aiming to provide new ideas for optimizing the clinical management of CTD-ILD.
作者
杨腾月
蒲豆豆
于楠
YANG Tengyue;PU Doudou;YU Nan(School of Medical Technology,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Medical Imaging,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《磁共振成像》
北大核心
2025年第3期167-172,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
陕西省教育厅青年创新团队科研计划项目(编号:23JP036)。
关键词
结缔组织病相关间质性肺病
磁共振成像
超短回波时间序列
超极化^(129)Xe磁共振成像
分子成像
connective tissue disease-related interstitial lung disease
magnetic resonance imaging
ultrashort echo time series
hyperpolarized 129Xe magnetic resonance imaging
molecular imaging
