摘要
目的观察慢性阻塞性肺疾病(COPD)患者上消化道出血发生情况,分析其危险因素,为COPD患者上消化道出血的防治提供参考。方法回顾性分析某院2021年12月26日—2023年4月30日期间收治的220例COPD患者的临床资料,根据是否发生上消化道出血将220例患者分为出血组(46例)和非出血组(174例),比较出血组和非出血组一般资料和临床资料,分析COPD患者发生上消化道出血的独立危险因素。结果出血组在年龄、病程、肺功能分级、服用抗凝药物、合并消化性溃疡、严重感染、外周血白蛋白(ALB)、pH值、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)与非出血组差异有统计学意义,2组其他一般资料和临床资料差异无统计学意义。多因素Logistic回归分析显示年龄、COPD病程、肺功能分级、合并消化性溃疡、合并严重感染、外周血ALB、PH值均为发生上消化道出血的危险因素。结论COPD患者上消化道出血发生率较高,患者年龄、病程、肺功能分级、合并消化性溃疡、严重感染、外周血ALB水平、pH值均为COPD患者上消化道出血的独立危险因素。
Objectives This study aims to observe the incidence of upper gastrointestinal bleeding in patients with chronic obstructive pulmonary disease(COPD)and analyze its risk factors,so as to provide reference for the prevention and treatment of upper gastrointestinal bleeding in COPD patients.Methods The clinical data of 220 patients with COPD admitted to a hospital from December 26,2021 to April 30,2023 were retrospectively analyzed.According to whether Upper gastrointestinal bleeding occurred,220 patients were divided into bleeding group(46 cases)and non-bleeding group(174 cases).The general and clinical data of bleeding group and non-bleeding group were compared,and the independent risk factors of upper gastrointestinal bleeding in COPD patients were analyzed.Results The bleeding group had statistically significant differences from the non-bleeding group in age,disease course,lung function grade,anticoagulant medication,combined peptic ulcer,severe infection,peripheral blood albumin(ALB),pH value,prothrombin time(PT),and activated partial thromboplastin time(APTT).There were no statistically significant differences in other general and clinical data between the two groups.Multivariate logistic regression analysis showed that age,COPD course,lung function grade,combined peptic ulcer,combined severe infection,peripheral blood ALB and pH value were risk factors for upper gastrointestinal bleeding.Conclusions The incidence of upper gastrointestinal bleeding in COPD patients is high.Patient age,disease course,lung function grade,combined peptic ulcer,severe infection,peripheral blood ALB level and pH value are all independent risk factors for upper gastrointestinal bleeding in COPD patients.
作者
刘萍
黄芳
林贵德
卢惠伦
Liu Ping;Huang Fang;Lin Guide;Lu Huilun(Department of medicine,Shenzhen Longgang District Second People’s Hospital,Shenzhen 518112,Guangdong Province,China;不详)
出处
《中国病案》
2025年第3期52-55,共4页
Chinese Medical Record
关键词
慢性阻塞性肺疾病
肺功能分级
严重感染
上消化道出血
危险因素1
Chronic obstructive pulmonary disease
Lung function grading
Severe infection
Upper gastrointestinal bleeding
Risk factors
