摘要
类风湿关节炎(RA)是一种以侵蚀性关节炎为主要表现的全身性自身免疫性疾病,最终可致关节畸形和功能丧失,但其发病机制至今仍未明确。自噬是细胞通过自我降解以重新利用细胞内蛋白质和细胞器的过程,有助生物体抵御饥饿或者感染等不利条件,最终使细胞能够继续生存。近年来大量研究发现,在RA发病过程中,血管翳的生成、滑膜炎症和骨破坏等关键的病理环节都与自噬异常有关,并且影响着RA的进展和预后。本文对自噬在RA的发病机制进行综述,为今后RA的治疗及新药研发提供新思路。
Rheumatoid arthritis(RA)is a systemic inflammatory disease characterized by erosive arthritis that can eventually lead to joint deformity and loss of function,which is unknown.Autophagy is a self-degradation process in which cells reuse internal proteins and organelles allowing organisms to withstand adverse situations such as starvation and infection,and eventually allowing cells to survive.In recent years,many studies have discovered that autophagy plays a role in the pathogenesis of RA,including the production of pannus,synovitis,bone degradation,and other critical pathological connections that influence RA progression and prognosis.This article examines the function of autophagy in the pathogenesis of RA,with the goal of generating new ideas for future RA treatment and drug development.
作者
李丽萍
夏培哲
沈嫦娟
谢希
LI Liping;XIA Peizhe;SHEN Changjuan;XIE Xi(Department of Rheumatology and Immunology,the Second Xiangya Hospital,Central South University,Changsha 410011,China)
出处
《中国免疫学杂志》
北大核心
2025年第4期1004-1009,共6页
Chinese Journal of Immunology
基金
国家自然科学基金(81873882)。
关键词
类风湿关节炎
自噬
发病机制
Rheumatoid arthritis
Autophagy
Pathogenesis
