摘要
The m^(6)A modification is an RNA modification that impacts various processes of RNA molecules,including transcription,splicing,stability,and translation.Recently,researchers have discovered that the presence of m^(6)A modification can influence the interaction between tumor cells and immune cells and also play a role in regulating the expression of immune response-related genes.Additionally,m^(6)A modification is intricately involved in the regulation of tumor immune evasion and drug resistance.Specifically,certain tumor cells can manipulate the gene expression through m^(6)A modification to evade immune system attacks.Therefore,it might be possible to enhance tumor immune surveillance and improve the effectiveness of immune-based therapies by manipulating m^(6)A modification.This review systematically discusses the role of m6A modification in tumor immunity,specifically highlighting its regulation of immune cells and immune-related genes in tumor cells.Furthermore,we explore the potential of m6A modification inhibitors as anti-cancer therapies and the significance of m6A regulatory factors in predicting the efficacy of tumor immune therapy.
基金
supported by the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21042)
the National Natural Science Foundation of China(82203447)。
