摘要
The rising incidence and death rates linked to Alzheimer's disease(AD)highlight an urgent issue.Genetic screening is celebrated as a significant advancement for its early detection capabilities,pinpointing those at risk before the emergence of symptoms.Yet,the limited availability of these technologies highlights a critical gap in widespread application.This review pivots to the potential of presymptomatic clinical assessments as a readily available,economical,and simple strategy for early detection.Traditionally,AD diagnosis relies on the late-stage identification of cognitive deterioration,functional impairments,and neuropsychiatric symptoms,coinciding with advanced brain degeneration.Conversely,emerging research identifies early indicators preceding significant degeneration,manifesting years before clinical symptoms.We introduce a mnemonic,MEMORIES,to categorize these prodromal:Metabolism changes,Eye/visual impairments,March(refer to gait disturbances),Olfactory dysfunction,Rhythm(blood pressure and heart rate),Insensitivity of the tongue,Ears(hearing loss),and Stool alterations.Recognizing these prodromal through clinical examinations provides a valuable strategy for initiating preventative actions against brain degeneration.This approach advocates for broadening the screening lens beyond genetic screening to encompass clinical evaluations,enhancing early detection and intervention opportunities for AD.
